INT191017

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 28
Disease Relevance 13.94
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd79a)
Anatomy Link Frequency
lymphocytes 4
epithelial cells 3
B cells 2
nasal 2
lamina 2
Cd79a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 278 100.00 Very High Very High Very High
Inflammation 199 98.64 Very High Very High Very High
Bile 83 97.08 Very High Very High Very High
chemokine 36 78.00 Quite High
abdominal pain 4 71.32 Quite High
Inflammatory response 12 63.92 Quite High
Crohn's disease 37 19.84 Low Low
antagonist 3 12.68 Low Low
MU agonist 2 12.08 Low Low
Calcium channel 24 10.48 Low Low
Disease Link Frequency Relevance Heat
Severe Combined Immunodeficiency 4 99.32 Very High Very High Very High
Disease 97 98.68 Very High Very High Very High
INFLAMMATION 201 98.64 Very High Very High Very High
Mitral Valve Prolapse 36 98.18 Very High Very High Very High
Respiratory Syncytial Virus 97 97.32 Very High Very High Very High
Infection 365 97.24 Very High Very High Very High
Obstructive Jaundice 56 96.48 Very High Very High Very High
Epstein-barr Virus 24 96.38 Very High Very High Very High
Chlamydia Infection 145 95.56 Very High Very High Very High
Necrosis 18 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These IEC transport the secreted IgA from the intestinal lamina propria across to the intestinal lumen and therefore play an important role in mucosal immune responses.
Localization (secreted) of IgA in intestinal lumen
1) Confidence 0.56 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.37 Pain Relevance 0.26
HET might modulate cytokine secretion of IEC, and the mucosal IgA antibody secretion might be enhanced through action of these cytokines.
Localization (secretion) of IgA associated with cytokine
2) Confidence 0.56 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.31 Pain Relevance 0.27
Note: in our preliminary experiment, the administration of OVA free blank microparticles did not induce IgA immune response in gastric mucosa (data not shown).
Localization (response) of IgA
3) Confidence 0.52 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.21 Pain Relevance 0
However, detailed mechanism is not known how HET enhanced IgA immune response in nasal tissues distant from intestine.
Localization (response) of IgA in nasal
4) Confidence 0.52 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0 Pain Relevance 0
The mechanism of enhancement of IgA response by HET still remains obscure.
Localization (response) of IgA
5) Confidence 0.52 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.05 Pain Relevance 0
The fact that we could not detect significant M2e(pep-nat)-specific IgA in pooled sera of i.n. vaccinated mice (data not shown) does not exclude the possibility that M2e(pep-nat)-specific IgA was produced locally and efficiently transported into airway secretions.
Localization (secretions) of IgA
6) Confidence 0.47 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.07 Pain Relevance 0
Nevertheless, cell-bound secretory IgA, while incapable of activating effector cells through one of the widely expressed activating Fc?
Localization (secretory) of IgA
7) Confidence 0.47 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.09 Pain Relevance 0
After its release into airway secretions, secretory M2e(pep-nat)-specific IgA may have lesser protective power than IgG, both in terms of activation of FcR-expressing effector cells and complement.
Localization (secretions) of IgA
8) Confidence 0.41 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.10 Pain Relevance 0
After its release into airway secretions, secretory M2e(pep-nat)-specific IgA may have lesser protective power than IgG, both in terms of activation of FcR-expressing effector cells and complement.
Localization (release) of IgA
9) Confidence 0.41 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.10 Pain Relevance 0
Changes in intestinal flora have been known to modulate mucosal lymphocytes that secrete Th2-type cytokines and antibodies, such as IL-10 and IgA, respectively [25].
Localization (secrete) of IgA in lymphocytes associated with cytokine
10) Confidence 0.39 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0 Pain Relevance 0.10
It has been known that Th2-type lymphocytes and plasma cells in the intestinal mucosa secrete IL-10 and IgA, respectively [25].
Localization (secrete) of IgA in lymphocytes
11) Confidence 0.37 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.56 Pain Relevance 0.25
These observations suggest that a lack of bile juice changed the intestinal flora, thereby stimulating Th2-type lymphocytes in the intestinal mucosa to produce IL-10 and subsequently increase IgA secretion.
Localization (secretion) of IgA in lymphocytes associated with bile
12) Confidence 0.37 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275763 Disease Relevance 0.51 Pain Relevance 0.23
Mucosal, as opposed to systemic vaccination is often more efficacious against mucosal pathogens due to their ability to induce secretory IgA [1], [2].
Localization (secretory) of IgA
13) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.51 Pain Relevance 0.07
The function of the gut barrier depends on mucous epithelia (mechanical barrier) and secreting IgA and immune cells (immune barrier) [35].
Localization (secreting) of IgA in immune cells
14) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.06 Pain Relevance 0.03
Whey peptides have recently been shown to possess immunomodulatory activities such as a stimulation of lymphocytes, an increasing in phagocytosis process as well as in secretion of immunoglobulin A (IgA) by Peyer's patches [5,13,17,20].
Localization (secretion) of IgA in lymphocytes
15) Confidence 0.26 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1845142 Disease Relevance 0.95 Pain Relevance 0.24
Third, secretory IgA antibodies play a central role in protecting mucosal surfaces against infections by blocking the entry of pathogens into target epithelial cells and/or by forming immune complexes that will be trapped into mucus, a defense mechanism referred to as immune exclusion [43].
Localization (secretory) of IgA in epithelial cells associated with infection
16) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 1.25 Pain Relevance 0.05
We tested the ability of vaults expressing (cp-MVP-z) or lacking (cp-MVP) the Fc binding peptide to adhere to mouse Ig isotypes which are generally found in nasal secretions (IgG and IgA) using an ELISA assay.
Localization (secretions) of IgA in nasal associated with mitral valve prolapse
17) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.93 Pain Relevance 0
High levels of IgA in cervical secretions in infected women correlate with low numbers of C. trachomatis shedding and B cells are required to eliminate Chlamydia in a secondary infection [35].
Localization (secretions) of IgA in B cells associated with chlamydia infection and infection
18) Confidence 0.19 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.63 Pain Relevance 0.13
In particular, IgA Ab-secreting cells predominantly populate the lamina propria of the mucosa.
Localization (secreting) of IgA in lamina
19) Confidence 0.18 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.84 Pain Relevance 0.19
EBV encodes a viral IL-10 homolog, BCRF1 (or vIL-10), that has been shown to increase human B cell proliferation following surface immunoglobulin crosslinkinking and induce B cells to secrete increased levels of IgM, IgG, and IgA in a similar manner to cellular IL-10 [17].
Localization (secrete) of IgA in B cells associated with epstein-barr virus
20) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.69 Pain Relevance 0

General Comments

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