INT19104

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Context Info
Confidence 0.40
First Reported 1980
Last Reported 2010
Negated 5
Speculated 5
Reported most in Body
Documents 24
Total Number 29
Disease Relevance 8.42
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
pituitary 4
ovary 3
blood 2
plasma 2
thyroid 2
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 19 100.00 Very High Very High Very High
Somatostatin 356 98.92 Very High Very High Very High
antagonist 18 95.96 Very High Very High Very High
Pain 26 93.92 High High
Morphine 4 92.48 High High
opiate 1 92.16 High High
Analgesic 2 91.28 High High
Opioid 1 89.84 High High
narcan 2 89.24 High High
Endogenous opioid 1 89.20 High High
Disease Link Frequency Relevance Heat
Stress 25 100.00 Very High Very High Very High
Targeted Disruption 25 100.00 Very High Very High Very High
Obesity 23 99.84 Very High Very High Very High
Hypopituitarism 14 99.82 Very High Very High Very High
Disease 175 99.42 Very High Very High Very High
Aging 125 98.76 Very High Very High Very High
Acromegaly 445 98.40 Very High Very High Very High
Disease Progression 9 96.28 Very High Very High Very High
Carcinoid 94 95.08 Very High Very High Very High
Lifespan 63 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no difference in GH suppressive effect in a small study in 7 patients in whom the 24 h GH secretion was precisely measured with a 10 min blood sampling protocol.
Neg (no) Regulation (difference) of Gene_expression (effect) of GH in blood
1) Confidence 0.40 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0 Pain Relevance 0.03
There are three hypothalamic factors or peptide systems that regulate GH synthesis and secretion (Figure 1): somatostatin (SRIF), GHRH, and ghrelin (Anawalt and Merriam 2001; Melmed 2006).
Regulation (regulate) of Gene_expression (synthesis) of GH associated with somatostatin
2) Confidence 0.39 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.14 Pain Relevance 0.10
It has been shown that thyroid hormones are positive regulators of GH synthesis and secretion.
Regulation (regulators) of Gene_expression (synthesis) of GH in thyroid
3) Confidence 0.35 Published 1993 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 8307113 Disease Relevance 0.08 Pain Relevance 0.34
In a second study indoprofen (400 mg, i.v., three times daily for 7 days) did not modify the PRL response to thyrotropin-releasing hormone nor serum GH levels.
Regulation (response) of Gene_expression (levels) of GH
4) Confidence 0.28 Published 1983 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 6354944 Disease Relevance 0.32 Pain Relevance 0.83
Total GH output (258 +/- 99 U vs 222 +/- 135 U), total number of nocturnal GH pulses (3.6 +/- 0.8 vs 3.3 +/- 1.3), mean peak GH response during nocturnal sampling (13 +/- 1.2 ng/ml vs 13.2 +/- 1.3 ng/ml), and basal somatomedin C concentrations were not different in the children with growth delay and controls.
Neg (not) Regulation (different) of Gene_expression (pulses) of GH
5) Confidence 0.27 Published 1986 Journal J. Pediatr. Section Abstract Doc Link 3772658 Disease Relevance 0 Pain Relevance 0.09
After thoracic surgery and under octreotide treatment GH secretion pattern visually normalized

GH secretory profiles

Regulation (normalized) of Gene_expression (profiles) of GH in thoracic
6) Confidence 0.26 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.47 Pain Relevance 0
Identification of genes affected by GH and IGF-I suppression is an important step towards understanding how this axis impacts longevity.
Regulation (affected) of Gene_expression (suppression) of GH associated with aging
7) Confidence 0.25 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.82 Pain Relevance 0
Postoperative radiation therapy is associated with a high incidence of hypopituitarism and its effect on growth hormone (GH) production is slow, so that adjuvant medical treatment becomes of importance in the management of many patients.


Regulation (effect) of Gene_expression (production) of GH associated with hypopituitarism
8) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Abstract Doc Link PMC2721386 Disease Relevance 0.43 Pain Relevance 0
In conclusion, the neuroregulation of GH release seems to be similar qualitatively in normal-weight and obese youngsters; the different behavior observed after arginine, which is supposed to act through somatostatin inhibition, might be due to a chronic increase in somatostatinergic tone responsible for the lower stimulated GH levels in obesity.
Regulation (responsible) of Gene_expression (levels) of GH associated with obesity and somatostatin
9) Confidence 0.23 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7788012 Disease Relevance 0.58 Pain Relevance 0.30
Total GH output (258 +/- 99 U vs 222 +/- 135 U), total number of nocturnal GH pulses (3.6 +/- 0.8 vs 3.3 +/- 1.3), mean peak GH response during nocturnal sampling (13 +/- 1.2 ng/ml vs 13.2 +/- 1.3 ng/ml), and basal somatomedin C concentrations were not different in the children with growth delay and controls.
Neg (not) Regulation (different) of Gene_expression (response) of GH
10) Confidence 0.23 Published 1986 Journal J. Pediatr. Section Abstract Doc Link 3772658 Disease Relevance 0 Pain Relevance 0.09
In fish models, norepinephrine (NE) inhibits GH release at the pituitary cell level, but its effects on GH synthesis have yet to be determined.
Regulation (effects) of Gene_expression (synthesis) of GH in pituitary
11) Confidence 0.22 Published 2007 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 17311897 Disease Relevance 0 Pain Relevance 0.19
In Exp. 2, crossbred wethers (36 +/- 2 kg; n = 12) were used to determine the effect of chronic administration (s.c.) of FK33-824 on the concentrations of GH and LH and retention of N and energy.
Spec (determine) Regulation (effect) of Gene_expression (concentrations) of GH
12) Confidence 0.20 Published 1991 Journal J. Anim. Sci. Section Abstract Doc Link 2016203 Disease Relevance 0 Pain Relevance 0.19
The purpose of that analysis was to determine whether GH replacement has any beneficial effect on psychological variables.
Spec (whether) Regulation (effect) of Spec (whether) Gene_expression (replacement) of GH
13) Confidence 0.17 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1277839 Disease Relevance 0 Pain Relevance 0
Influence of hypothalamus and ovary on pituitary function in transgenic mice expressing the bovine growth hormone gene and in growth hormone-deficient Ames dwarf mice.
Regulation (Influence) of Gene_expression (expressing) of growth hormone gene in ovary associated with targeted disruption
14) Confidence 0.17 Published 1996 Journal Biol. Reprod. Section Title Doc Link 8722619 Disease Relevance 0.34 Pain Relevance 0.05
The combined criterion of GH levels ? 
Regulation (criterion) of Gene_expression (levels) of GH
15) Confidence 0.15 Published 2009 Journal Pituitary Section Body Doc Link PMC2807598 Disease Relevance 0 Pain Relevance 0
Twelve months’ treatment with octreotide long-acting repeatable (LAR), achieved GH levels < 2.5 ng/ml in 54% of patients and normalized IGF-1 in 61%.
Regulation (normalized) of Gene_expression (levels) of GH
16) Confidence 0.15 Published 2009 Journal Pituitary Section Body Doc Link PMC2807598 Disease Relevance 0.23 Pain Relevance 0.15
After a further three injections of Lan-Autogel in the fixed-dose phase, control of GH and IGF-1 levels continued to improve.
Regulation (control) of Gene_expression (levels) of GH
17) Confidence 0.15 Published 2009 Journal Pituitary Section Body Doc Link PMC2807598 Disease Relevance 0 Pain Relevance 0
2.5 ng/ml; 59% of patients had normalized IGF-1 levels, and 43% had both GH levels ? 
Regulation (had) of Gene_expression (levels) of GH
18) Confidence 0.15 Published 2009 Journal Pituitary Section Body Doc Link PMC2807598 Disease Relevance 0 Pain Relevance 0
Seven studies have reported the value of GH or IGF-I levels in predicting premature mortality from acromegaly, however only one study formally measured GH and IGF-I in all subjects.
Regulation (value) of Gene_expression (levels) of GH associated with acromegaly
19) Confidence 0.11 Published 2009 Journal Pituitary Section Body Doc Link PMC2913001 Disease Relevance 0.50 Pain Relevance 0
A few studies have examined the degree of improvement in GH and IGF-I levels after surgery, studying the correlation of biochemical responses with improvement in signs or symptoms of disease activity.
Spec (examined) Regulation (degree) of Gene_expression (levels) of GH associated with disease
20) Confidence 0.11 Published 2009 Journal Pituitary Section Body Doc Link PMC2913001 Disease Relevance 0.21 Pain Relevance 0

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