INT191050

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.82
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
ZR-75-1 2
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 23 90.08 High High
aspirin 9 75.88 Quite High
corticosteroid 3 71.28 Quite High
Inflammation 73 59.76 Quite High
fibrosis 1 47.56 Quite Low
Inflammatory stimuli 6 40.04 Quite Low
cytokine 15 36.52 Quite Low
Pain 12 16.64 Low Low
COX-2 inhibitor 18 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 10 95.64 Very High Very High Very High
Hyperoxia 49 91.28 High High
Pressure And Volume Under Development 1 88.08 High High
Body Weight 4 84.72 Quite High
Breast Cancer 30 80.72 Quite High
Retinoblastoma 3 69.84 Quite High
Apoptosis 43 69.24 Quite High
Lung Injury 2 64.32 Quite High
Bronchopulmonary Dysplasia 10 60.80 Quite High
INFLAMMATION 80 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because downregulation of Bcl-2 by AS Bcl-2 might result in downregulation of pAkt, downregulation of pAkt after treatment with DOX might be augmented by concurrent treatment of ZR-75-1 cells with AS Bcl-2.
Positive_regulation (augmented) of Negative_regulation (downregulation) of pAkt in ZR-75-1
1) Confidence 0.31 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.30 Pain Relevance 0
Western blot performed on cardiac tissue lysates demonstrates that Akt and NFAT3 activity (decreased by phosphorylation) are increased in mice in the myostatin inhibition group and decreased in mice in the myostatin overexpression group (Fig. 10A, B).
Positive_regulation (increased) of Negative_regulation (decreased) of Akt
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 0.05 Pain Relevance 0
A number of kinases, such as AKT and MEK kinases, activate IKK.
Positive_regulation (activate) of Negative_regulation (number) of AKT
3) Confidence 0.17 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.17 Pain Relevance 0.32
A number of kinases, such as AKT and MEK kinases, activate IKK.
Positive_regulation (activate) of Negative_regulation (number) of kinases
4) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.17 Pain Relevance 0.32
A number of kinases, such as AKT and MEK kinases, activate IKK.
Positive_regulation (activate) of Negative_regulation (number) of kinases
5) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.17 Pain Relevance 0.32
Indeed, rolipram also induced by itself a decrease of absolute alveolar-surface area and RAC in pups maintained in air.
Positive_regulation (induced) of Negative_regulation (decrease) of RAC
6) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2563688 Disease Relevance 0.95 Pain Relevance 0.08

General Comments

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