INT19107

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Context Info
Confidence 0.62
First Reported 1981
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 12.54
Pain Relevance 8.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 4
plasma 2
LAD 2
smooth muscle cells 2
coronary sinus 1
Tbxa2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 18 100.00 Very High Very High Very High
Inflammation 15 100.00 Very High Very High Very High
ischemia 29 99.92 Very High Very High Very High
Angina 48 99.86 Very High Very High Very High
Serotonin 11 99.80 Very High Very High Very High
aspirin 19 98.94 Very High Very High Very High
withdrawal 5 98.80 Very High Very High Very High
Clonidine 8 98.00 Very High Very High Very High
cva 16 97.76 Very High Very High Very High
Catecholamine 4 97.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 19 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 19 100.00 Very High Very High Very High
Coronary Artery Disease 13 99.92 Very High Very High Very High
Angina 23 99.86 Very High Very High Very High
Cv General 3 Under Development 27 99.66 Very High Very High Very High
Disease 1 99.58 Very High Very High Very High
Dyspnea 12 99.40 Very High Very High Very High
Bacterial Respiratory Disease 2 99.28 Very High Very High Very High
Syndrome 4 98.92 Very High Very High Very High
Hypertension 8 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma levels of thromboxane A2 (TXA2), an inflammatory mediator inducing platelet aggregation, bronchoconstriction, and vasoconstriction, are increased in the perioperative period.
Positive_regulation (increased) of thromboxane A2 in platelet associated with inflammation and increased venous pressure under development
1) Confidence 0.62 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15281511 Disease Relevance 0.54 Pain Relevance 0.35
Plasma levels of thromboxane A2 (TXA2), an inflammatory mediator inducing platelet aggregation, bronchoconstriction, and vasoconstriction, are increased in the perioperative period.
Positive_regulation (increased) of TXA2 in platelet associated with inflammation and increased venous pressure under development
2) Confidence 0.62 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15281511 Disease Relevance 0.54 Pain Relevance 0.35
These results show that TXA2 produced in smooth muscle cells is increased in mesenteric arteries from orchidectomized rats compared to their controls, and that this prostanoid is functionally involved in the vasoconstrictor response to clonidine only in arteries from the orchidectomized rats.
Positive_regulation (increased) of TXA2 in smooth muscle cells associated with clonidine
3) Confidence 0.55 Published 2006 Journal J. Vasc. Res. Section Abstract Doc Link 16293968 Disease Relevance 0 Pain Relevance 0.64
BACKGROUND AND OBJECTIVES: Thromboxane A2 (TXA2) activation is involved in several pathophysiological states in producing pulmonary hypertension.
Positive_regulation (activation) of Thromboxane A2 associated with hypertension and local anesthetic
4) Confidence 0.43 Published 2000 Journal Reg Anesth Pain Med Section Abstract Doc Link 10746533 Disease Relevance 0.17 Pain Relevance 0.28
BACKGROUND AND OBJECTIVES: Thromboxane A2 (TXA2) activation is involved in several pathophysiological states in producing pulmonary hypertension.
Positive_regulation (activation) of TXA2 associated with hypertension and local anesthetic
5) Confidence 0.43 Published 2000 Journal Reg Anesth Pain Med Section Abstract Doc Link 10746533 Disease Relevance 0.17 Pain Relevance 0.28
Recent studies show a temporal relationship between acute ischemic events (specifically, unstable angina) and a transcardiac increase in thromboxane B2, while others demonstrate a salutary effect of disaggregatory and vasodilatory prostaglandins in such patients.
Positive_regulation (increase) of thromboxane B2 associated with angina
6) Confidence 0.37 Published 1981 Journal Am. J. Med. Section Abstract Doc Link 7032286 Disease Relevance 0.95 Pain Relevance 0.13
Our results indicate that rapid withdrawal of ASA, may cause abnormally high 12-HHT levels reflecting increase of thromboxane A2 with possible hazardous effects in patients with cardiovascular disease.
Spec (possible) Positive_regulation (increase) of thromboxane A2 associated with aspirin, cardiovascular disease and withdrawal
7) Confidence 0.37 Published 1996 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 8845467 Disease Relevance 0.40 Pain Relevance 0.53
CONCLUSION: The increased concentrations of thromboxane B(2) between 1 and 2.5 hours of halothane anesthesia and during the corresponding stages of the surgical intervention suggested that the anesthetic technique caused a significant increase in thromboxane B(2) and that surgery did not appear to contribute to this response.


Positive_regulation (increase) of thromboxane B
8) Confidence 0.31 Published 2004 Journal Vet Anaesth Analg Section Body Doc Link 15053753 Disease Relevance 0 Pain Relevance 0
CONCLUSION: The increased concentrations of thromboxane B(2) between 1 and 2.5 hours of halothane anesthesia and during the corresponding stages of the surgical intervention suggested that the anesthetic technique caused a significant increase in thromboxane B(2) and that surgery did not appear to contribute to this response.


Positive_regulation (increased) of thromboxane B
9) Confidence 0.31 Published 2004 Journal Vet Anaesth Analg Section Body Doc Link 15053753 Disease Relevance 0 Pain Relevance 0
Although MK-447 alone at 1 and 10 microM had no significant effects, MK-447 at 100 microM stimulated both PGI2 and TXA2 biosynthesis, and suppressed the lipid peroxidation in the pulp tissue as estimated by thiobarbituric acid method.
Positive_regulation (stimulated) of TXA2
10) Confidence 0.30 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3921031 Disease Relevance 0.16 Pain Relevance 0.12
Serum thromboxane B2 concentration is normal on the first day and increases gradually in the course of 14 days (p less than 0.05) to values which are not significantly different from those observed in patients with unstable angina pectoris.
Positive_regulation (increases) of thromboxane B2 associated with angina
11) Confidence 0.29 Published 1990 Journal Ugeskr. Laeg. Section Abstract Doc Link 2275044 Disease Relevance 1.02 Pain Relevance 0.64
Significant increase of neuropeptide Y and thromboxane B2 plasma levels in variant angina patients during artery coronary spasm induced by hyperventilation test suggests the contribution of these humoral factors to the pathogenesis of vasospastic episodes in angina patients.
Positive_regulation (increase) of thromboxane B2 in artery associated with angina, neuropeptide, cva and dyspnea
12) Confidence 0.27 Published 1998 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 10335040 Disease Relevance 1.38 Pain Relevance 1.21
At the end of hyperventilation test in variant angina group thromboxane B2 level significantly increased and remained on this level until 10 min. after the test.
Positive_regulation (increased) of thromboxane B2 associated with angina and dyspnea
13) Confidence 0.27 Published 1998 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 10335040 Disease Relevance 1.37 Pain Relevance 1.22
Transcardiac accumulation of thromboxane A2 and serotonin has been demonstrated in patients as chronic stable angina is converted to unstable angina.
Positive_regulation (accumulation) of thromboxane A2 associated with angina and serotonin
14) Confidence 0.26 Published 1991 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 2016468 Disease Relevance 0.84 Pain Relevance 0.42
Following occlusion of the LAD, there was an increase in thromboxane B2 concentration from 0.77 +/- 0.0093 to 1.79 +/- 0.46 pmol/ml (p less than 0.05) and 1.96 +/- 0.48 pmol/ml (p less than 0.05) at 1 and 5 minutes, respectively, following coronary occlusion.
Positive_regulation (increase) of thromboxane B2 in LAD associated with coronary heart disease
15) Confidence 0.24 Published 1984 Journal Am. Heart J. Section Abstract Doc Link 6485997 Disease Relevance 0.49 Pain Relevance 0.07
Accumulation of TXA2 favors platelet aggregation, vasoconstriction, and smooth muscle cell proliferation.
Positive_regulation (Accumulation) of TXA2 in smooth muscle cell associated with increased venous pressure under development
16) Confidence 0.09 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.61 Pain Relevance 0.15
In patients with lactate production given placebo, a 64 +/- 25% increase in the thromboxane B2 level and a 113 +/- 37% increase in cathepsin D activities occurred in the coronary sinus effluent sampled after pacing.
Positive_regulation (increase) of thromboxane B2 in coronary sinus
17) Confidence 0.04 Published 1983 Journal Am. J. Cardiol. Section Abstract Doc Link 6829434 Disease Relevance 0.52 Pain Relevance 0.28
Intravenous infusion of Pasteurella hemolytica endotoxin caused marked increases in the plasma levels of thromboxane B2 (TxB2), prostaglandins (PG) and serotonin in sheep.
Positive_regulation (increases) of thromboxane B2 in plasma associated with bacterial respiratory disease and serotonin
18) Confidence 0.01 Published 1985 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 3867760 Disease Relevance 0.25 Pain Relevance 0.13
CA patients showed increased basal levels of beta-thromboglobulin and thromboxane B2 compared to control patients and normal plasma levels of catecholamines.
Positive_regulation (increased) of thromboxane B2 in plasma associated with angina and catecholamine
19) Confidence 0.00 Published 1995 Journal Pharmacol. Res. Section Abstract Doc Link 8668647 Disease Relevance 0.46 Pain Relevance 0.51
We suggest that decreases in PGE2 and PGI2 in models of airway disease in combination with increases in LTC4, LTD4, and thromboxane A2 may contribute to airway hyperresponsiveness in vitro.
Positive_regulation (increases) of thromboxane A2 in PGE2 associated with disease
20) Confidence 0.00 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8179018 Disease Relevance 0.10 Pain Relevance 0

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