INT191073

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Context Info
Confidence 0.53
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.99
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) cytoplasm (Mki67)
Anatomy Link Frequency
GBM 2
RG2 2
Mki67 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 6 78.32 Quite High
imagery 20 72.60 Quite High
positron emission tomography 44 43.12 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 485 99.00 Very High Very High Very High
Glioblastoma 76 98.88 Very High Very High Very High
Apoptosis 70 97.16 Very High Very High Very High
Breast Cancer 69 95.08 Very High Very High Very High
Osteogenic Sarcomas 30 87.92 High High
Body Weight 4 87.64 High High
Cv General 3 Under Development 7 78.32 Quite High
Metastasis 36 76.00 Quite High
Advanced Or Metastatic Breast Cancer 62 75.44 Quite High
Immunotherapy Of Cancer 11 72.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was further validated by a similar decrease in Ki67 gene expression.
Negative_regulation (decrease) of Gene_expression (expression) of Ki67 gene
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.64 Pain Relevance 0.04
Immunohistochemistry revealed a strong positivity for the Ki67-antigen (Figure 3); the Ki67 index was between 41% and 48%, respectively

Intraperitoneal Tumours

Negative_regulation (was) of Gene_expression (index) of Ki67 associated with cancer
2) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527616 Disease Relevance 0.67 Pain Relevance 0
In the treatment group expression of Ki67 was significantly lower at 6 hours post injection (?
Negative_regulation (lower) of Gene_expression (expression) of Ki67
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0 Pain Relevance 0
A reduction in Ki67 expression, a surrogate marker of proliferation, was demonstrated in ER-positive tumors but not in those that overexpressed HER2 or in those with triple receptor-negative (TRN) breast cancer.


Negative_regulation (reduction) of Gene_expression (expression) of Ki67 associated with cancer and breast cancer
4) Confidence 0.14 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.55 Pain Relevance 0
Our study found a significant association between EFGR expression and proliferation marker Ki-67 (?
Negative_regulation (association) of Gene_expression (expression) of Ki-67
5) Confidence 0.08 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717822 Disease Relevance 0.37 Pain Relevance 0
As positive nuclear staining was homogenous, evaluation of Top IIa, KI 67 and p53 expression was done according to the percentage of positively stained cells only, regardless of the intensity.
Negative_regulation (evaluation) of Gene_expression (expression) of KI 67
6) Confidence 0.08 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410751 Disease Relevance 0.06 Pain Relevance 0
The immunohistochemistry results on day 16 after BP treatment showed a decrease in Ki-67 protein expression, an increase in cleaved caspase 3 protein expression and an increase in apoptosis in tumor cells relative to the control group in vivo (Fig. 4c); these results are similar to those shown in the subcutaneous RG2 tumor model.
Negative_regulation (decrease) of Gene_expression (expression) of Ki-67 in RG2 associated with cancer and apoptosis
7) Confidence 0.07 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 1.62 Pain Relevance 0
The human GBM tumor tissues with BP treatment in vivo also displayed decreases in Ki-67 expression, and increases in cleaved caspase 3 protein expression and tumor cell apoptosis, relative to the control group in vivo, at day 10 after treatment (Fig. 5d).


Negative_regulation (decreases) of Gene_expression (expression) of Ki-67 in GBM associated with cancer, glioblastoma and apoptosis
8) Confidence 0.05 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 1.07 Pain Relevance 0.08

General Comments

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