INT19109

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.48
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP3A5) oxidoreductase activity (CYP3A5) endoplasmic reticulum (CYP3A5)
Anatomy Link Frequency
liver 1
CYP3A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 8 99.74 Very High Very High Very High
Oxycodone 6 99.44 Very High Very High Very High
Versed 2 98.68 Very High Very High Very High
lidocaine 1 97.20 Very High Very High Very High
Dextromethorphan 2 85.60 High High
carbamazepine 2 82.64 Quite High
Bioavailability 6 79.56 Quite High
Morphine 1 77.24 Quite High
dexamethasone 1 76.24 Quite High
antagonist 10 75.00 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 99.40 Very High Very High Very High
Nicotine Addiction 2 97.64 Very High Very High Very High
Schizophrenia 37 95.28 Very High Very High Very High
Mycobacterial Infection 4 90.24 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 83.08 Quite High
Congenital Anomalies 2 79.04 Quite High
Fever 1 71.72 Quite High
Infection 1 70.00 Quite High
Psychosis 10 63.04 Quite High
Syndrome 6 44.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a pharmacological model substance for cytochrome p 450 enzymes, measurement of antipyrine in serum by high pressure liquid chromatography revealed induction of cytochrome p 450 isoenzymes.
Positive_regulation (induction) of cytochrome p 450
1) Confidence 0.67 Published 1991 Journal Klin. Wochenschr. Section Abstract Doc Link 2016843 Disease Relevance 0.30 Pain Relevance 0.08
These cases plus similar reports in the literature suggest that isoniazid or rifampin, or both, may potentiate the hepatotoxicity of acetaminophen, perhaps by induction of cytochrome P450 isozymes that oxidize acetaminophen to its toxic metabolites.
Positive_regulation (induction) of cytochrome P450 associated with paracetamol and hepatotoxicity
2) Confidence 0.67 Published 1994 Journal Chest Section Abstract Doc Link 7508362 Disease Relevance 0.70 Pain Relevance 0.59
The 24-hour urinary excretion of 6 beta-hydroxycortisol was increased in parallel by approximately 1.7-fold, indicating induction of cytochrome P450 3A isozymes.
Positive_regulation (induction) of cytochrome P450
3) Confidence 0.67 Published 1999 Journal J Clin Pharmacol Section Abstract Doc Link 10392325 Disease Relevance 0 Pain Relevance 0.08
CYP3A4 and CYP3A5 displayed the highest activity for oxycodone N-demethylation; intrinsic clearance for CYP3A5 was slightly higher than that for CYP3A4.
Positive_regulation (clearance) of CYP3A5 associated with oxycodone
4) Confidence 0.45 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 15039299 Disease Relevance 0 Pain Relevance 0.43
Based on this parameter, CYP3A5 was more active than CYP3A4 in catalyzing total midazolam hydroxylation (3-fold) and lidocaine demethylation (1.4-fold).
Positive_regulation (active) of CYP3A5 associated with versed and lidocaine
5) Confidence 0.38 Published 2004 Journal Drug Metab. Dispos. Section Abstract Doc Link 15383492 Disease Relevance 0 Pain Relevance 0.27
PK variations may be attributable to concurrent medications that inhibit or induce CYP3A4 or CYP3A5.
Positive_regulation (induce) of CYP3A5
6) Confidence 0.23 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0 Pain Relevance 0.08
This suggests it is unlikely to interact with drugs that inhibit or induce these enzymes.33 Also, smoking should not affect its pharmacokinetics, like most antipsychotics except the CYP1A2 substrates clozapine and olanzapine whose clearance is affected by cigarette smoking and drugs that induce or inhibit CYP1A2.21 In vitro studies in human liver microsomes showed that iloperidone do not induce CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP3A4 and CYP3A5.33

Efficacy

Neg (not) Positive_regulation (induce) of CYP3A5 in liver associated with nicotine addiction
7) Confidence 0.07 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846148 Disease Relevance 0.49 Pain Relevance 0

General Comments

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