INT19110

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 4.51
Pain Relevance 6.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Anatomy Link Frequency
liver 3
brain 3
margin 2
macrophages 1
adult central nervous system 1
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
MU agonist 1 99.72 Very High Very High Very High
Morphine 30 99.50 Very High Very High Very High
Central nervous system 2 99.44 Very High Very High Very High
Enkephalin 14 99.08 Very High Very High Very High
opioid receptor 17 97.72 Very High Very High Very High
mu opioid receptor 2 97.16 Very High Very High Very High
Kappa opioid receptor 1 97.04 Very High Very High Very High
antagonist 8 96.84 Very High Very High Very High
Opioid 16 96.36 Very High Very High Very High
Intracerebroventricular 4 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 2 100.00 Very High Very High Very High
Ulcers 13 99.68 Very High Very High Very High
Apoptosis 4 98.00 Very High Very High Very High
Alopecia 5 95.64 Very High Very High Very High
Peptic Ulcer 10 95.16 Very High Very High Very High
Convulsion 13 92.56 High High
Epilepsy 2 92.48 High High
Bordatella Infection 1 86.08 High High
Adrenal Cancer 7 84.04 Quite High
Hirsutism 31 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results provide the first description of ODC induction in an in vitro preparation of adult brain tissue and indicate that the hippocampal slice preparation could be used to study the molecular mechanisms which regulate the expression and activity of ODC in the adult central nervous system.
Gene_expression (expression) of ODC in adult central nervous system associated with central nervous system
1) Confidence 0.78 Published 1988 Journal Brain Res. Section Abstract Doc Link 2852984 Disease Relevance 0 Pain Relevance 0.41
The purpose of this study was to: (a) determine the temporal pattern of expression of ornithine decarboxylase (ODC), an established marker of cells engaged in proliferation and differentiation, during repair of traumatized skeletal muscle, and (b) evaluate ODC as a biochemical marker for indexing the extent and rate of repair of traumatized skeletal muscle in response to therapeutic agents.
Gene_expression (expression) of ODC in skeletal muscle
2) Confidence 0.78 Published 1991 Journal Life Sci. Section Abstract Doc Link 2016985 Disease Relevance 0.06 Pain Relevance 0.07
The inhibition of liver ornithine decarboxylase expression in neonatal rats by maternal separation or CNS beta-endorphin is independent of the pituitary.
Gene_expression (expression) of ornithine decarboxylase in pituitary
3) Confidence 0.78 Published 1994 Journal Life Sci. Section Title Doc Link 8107512 Disease Relevance 0 Pain Relevance 0.09
BE on liver ODC gene expression.
Gene_expression (expression) of ODC gene in liver
4) Confidence 0.78 Published 1994 Journal Life Sci. Section Abstract Doc Link 8107512 Disease Relevance 0 Pain Relevance 0.10
Since polyamines and ornithine decarboxylase (ODC), the rate-limiting enzyme in their synthesis, have been shown to play critical roles in the growth and differentiation of several types of tissue, we tested for changes in ODC activity at various times following the initiation of seizures.
Gene_expression (synthesis) of ODC associated with convulsion
5) Confidence 0.67 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3794781 Disease Relevance 0.38 Pain Relevance 0.32
Since polyamines and ornithine decarboxylase (ODC), the rate-limiting enzyme in their synthesis, have been shown to play critical roles in the growth and differentiation of several types of tissue, we tested for changes in ODC activity at various times following the initiation of seizures.
Gene_expression (synthesis) of ornithine decarboxylase associated with convulsion
6) Confidence 0.67 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3794781 Disease Relevance 0.38 Pain Relevance 0.33
The results obtained demonstrate that i.c.v. beta-endorphin downregulates ODC expression in central as well as in peripheral tissues by interacting with brain mu-opioid receptors, but not with delta- or epsilon-opioid receptors or mu/delta-opioid receptor complexes.
Gene_expression (expression) of ODC in brain associated with mu opioid receptor and opioid receptor
7) Confidence 0.67 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8549635 Disease Relevance 0 Pain Relevance 0.79
In conclusion, these results indicate that some opioid agonists can modulate ODC expression in non neural cells.
Gene_expression (expression) of ODC in neural associated with mu agonist
8) Confidence 0.63 Published 1998 Journal Mol. Cell. Biochem. Section Abstract Doc Link 9746211 Disease Relevance 0.09 Pain Relevance 0.44
Intracisternal administration of N alpha-acetyl-beta-endorphin evoked profound increases in brain ODC activity in 6- and 9-day-old rats, whereas normal ODC levels were observed in 25-day-old animals and in adult rats.
Gene_expression (levels) of ODC in brain
9) Confidence 0.54 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3559981 Disease Relevance 0 Pain Relevance 0.50
Thus, CNS morphine can apparently suppress tissue ornithine decarboxylase expression through both transcriptional and posttranscriptional mechanisms.
Gene_expression (expression) of tissue ornithine decarboxylase associated with morphine
10) Confidence 0.52 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.94
Cell apoptosis to cell proliferation ratio was strongly decreased and accompanied by significant up-regulation of ornithine decarboxylase (ODC) and B-cell lymphoma 2 (Bcl-2) protein expression at the ulcer margin.
Gene_expression (expression) of ODC in margin associated with lymphatic system cancer, ulcers and apoptosis
11) Confidence 0.48 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.23 Pain Relevance 0.07
Cell apoptosis to cell proliferation ratio was strongly decreased and accompanied by significant up-regulation of ornithine decarboxylase (ODC) and B-cell lymphoma 2 (Bcl-2) protein expression at the ulcer margin.
Gene_expression (expression) of ornithine decarboxylase in margin associated with lymphatic system cancer, ulcers and apoptosis
12) Confidence 0.48 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.24 Pain Relevance 0.07
In addition to these five genes, we have defined the “greater urea cycle” and also examined the expression of mRNA for nine additional enzymes that play a role in the disposal of nitrogen in the liver (glutamine synthetase, glutamine dehydrogenase, malate dehydrogenase, carbonic anhydrase, glutaminase, ornithine decarboxylase, tyrosine aminotransferase, aspartate aminotransferase and alanine aminotransferase), and two additional genes involved in transcriptional regulation of those genes; glucocorticoid receptor (GR) and CCAAT/enhancer binding protein (CEBP-?).
Spec (examined) Gene_expression (expression) of ornithine decarboxylase in liver
13) Confidence 0.42 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0.29 Pain Relevance 0.06
Intracerebroventricular (i.c.v.) injection of a single dose of morphine (2 microg) to 6-day-old rats markedly decreased basal brain and liver ornithine decarboxylase activity as well as the increases in hepatic ornithine decarboxylase activity produced by subcutaneously (s.c.) administered insulin, an important trophic hormone.
Gene_expression (produced) of ornithine decarboxylase in liver associated with intracerebroventricular and morphine
14) Confidence 0.40 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.52
Inhibition of the expression of ornithine decarboxylase by some kappa-opioidergic receptor ligands in difluoromethylornithine-resistant L1210 cells.
Gene_expression (expression) of ornithine decarboxylase in L1210
15) Confidence 0.24 Published 1996 Journal Biochim. Biophys. Acta Section Title Doc Link 8664348 Disease Relevance 0 Pain Relevance 0.28
In conclusion, the inhibition of ODC expression by U-50488H does not involve classical, enantiospecific opioid receptors; rather, these results suggest the involvement of a distinct site of action linked to inhibition of lymphoid cell proliferation.
Gene_expression (expression) of ODC associated with opioid receptor
16) Confidence 0.24 Published 1996 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8664348 Disease Relevance 0 Pain Relevance 0.37
A common expression for the ODC is the Hill equation (Eq. 1) which is parametrized by the P50 (the oxygen tension at which blood hemoglobin is 50% saturated by oxygen) and the Hill coefficient (h).
Gene_expression (expression) of ODC in blood
17) Confidence 0.14 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2899518 Disease Relevance 0 Pain Relevance 0
Intracerebroventricular (i.c.v.) injection of a single dose of morphine (2 microg) to 6-day-old rats markedly decreased basal brain and liver ornithine decarboxylase activity as well as the increases in hepatic ornithine decarboxylase activity produced by subcutaneously (s.c.) administered insulin, an important trophic hormone.
Gene_expression (produced) of ornithine decarboxylase in brain associated with intracerebroventricular and morphine
18) Confidence 0.13 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.52
When macrophages were cocultured with H. pylori, killing of bacteria was enhanced by transfection of ODC siRNA and prevented by addition of spermine.
Gene_expression (transfection) of ODC in macrophages
19) Confidence 0.12 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.23 Pain Relevance 0.10
It is a potent, irreversible inhibitor of the enzyme ornithine decarboxylase, which is necessary for production of the polyamines that mediate cell migration, proliferation, and differentiation.[26] Binding of DHT to the androgen receptor is associated with stimulation of ornithine decarboxylase synthesis and proliferation of hair matrix cells.
Gene_expression (production) of ornithine decarboxylase in hair
20) Confidence 0.01 Published 2010 Journal Indian Journal of Dermatology Section Body Doc Link PMC2856356 Disease Relevance 0.61 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox