INT191113

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.76
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr2) plasma membrane (Cnr2) signal transducer activity (Cnr2)
Anatomy Link Frequency
brain 4
macrophages 3
microglial cells 1
Cnr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 90 99.40 Very High Very High Very High
qutenza 12 98.60 Very High Very High Very High
Lasting pain 4 98.46 Very High Very High Very High
Inflammation 46 98.20 Very High Very High Very High
Peripheral nerve injury 2 97.78 Very High Very High Very High
Spinal nerve ligature 4 96.68 Very High Very High Very High
Sciatic nerve 2 96.16 Very High Very High Very High
alcohol 50 95.60 Very High Very High Very High
Morphine 2 95.12 Very High Very High Very High
cocaine 12 94.72 High High
Disease Link Frequency Relevance Heat
Stress 64 100.00 Very High Very High Very High
Pain 12 98.46 Very High Very High Very High
INFLAMMATION 50 98.20 Very High Very High Very High
Nervous System Injury 2 97.78 Very High Very High Very High
Multiple Sclerosis 8 86.36 High High
Demyelinating Disease 104 85.52 High High
Spasticity 2 84.68 Quite High
Tremor 2 84.08 Quite High
Disease 18 77.28 Quite High
Depression 74 75.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mouse model, the CB2 gene transcripts were present in whole brain preparations following CMS and CB2-R protein was enhanced by CMS and prenatal capsaicin exposure.
Positive_regulation (following) of Transcription (transcripts) of CB2 gene in brain associated with stress and qutenza
1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.58 Pain Relevance 0.79
In the mouse model, the CB2 gene transcripts were present in whole brain preparations following CMS and CB2-R protein was enhanced by CMS and prenatal capsaicin exposure.
Positive_regulation (following) of Transcription (present) of CB2-R in brain associated with stress and qutenza
2) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2241668 Disease Relevance 0.58 Pain Relevance 0.79
Chronic pain models (CCI or Bennett and Chung models, sciatic nerve and spinal nerve ligation, respectively) associated with peripheral nerve injury but not inflammatory chronic pain models (Freund's complete adjuvant injection in the paw) have been shown to induce CB2 mRNA expression in rat lumbar spinal cord on activated microglial cells/macrophages, in regions undergoing neuronal damage [49].
Positive_regulation (induce) of Transcription (expression) of CB2 in macrophages associated with nervous system injury, inflammation, spinal nerve ligature, lasting pain, sciatic nerve, spinal cord and peripheral nerve injury
3) Confidence 0.26 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 1.30 Pain Relevance 0.95
Chronic pain models (CCI or Bennett and Chung models, sciatic nerve and spinal nerve ligation, respectively) associated with peripheral nerve injury but not inflammatory chronic pain models (Freund's complete adjuvant injection in the paw) have been shown to induce CB2 mRNA expression in rat lumbar spinal cord on activated microglial cells/macrophages, in regions undergoing neuronal damage [49].
Positive_regulation (induce) of in microglial cells Transcription (expression) of CB2 in macrophages associated with nervous system injury, inflammation, spinal nerve ligature, lasting pain, sciatic nerve, spinal cord and peripheral nerve injury
4) Confidence 0.09 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 1.30 Pain Relevance 0.95

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox