INT191121

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.69
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2RX7) cytoplasm (P2RX7)
Anatomy Link Frequency
monocytes 2
P2RX7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 78 99.84 Very High Very High Very High
cytokine 15 94.80 High High
Inflammatory mediators 2 93.20 High High
Multiple sclerosis 49 75.92 Quite High
agonist 33 71.20 Quite High
Inflammatory stimuli 1 69.92 Quite High
Cannabinoid 14 65.00 Quite High
adenocard 28 56.16 Quite High
Neuropathic pain 2 55.96 Quite High
metalloproteinase 5 49.44 Quite Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 123 100.00 Very High Very High Very High
INFLAMMATION 85 99.84 Very High Very High Very High
Adhesions 9 97.40 Very High Very High Very High
Hypertension 48 94.68 High High
Disease 42 91.16 High High
Diabetes Mellitus 22 90.28 High High
Cardiovascular Disease 22 89.88 High High
Diabetic Angiopathy 2 83.76 Quite High
Necrosis 10 81.92 Quite High
Vasculitis 2 81.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IPC was responsible for the design and production of the P2X7 antibodies used, helped with interpretation of the data, and writing the manuscript.
Regulation (responsible) of Gene_expression (production) of P2X7
1) Confidence 0.36 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1413551 Disease Relevance 0.67 Pain Relevance 0.32
The upregulation of P2X7 expression in monocytes by TNF-?
Regulation (monocytes) of Gene_expression (expression) of P2X7 in monocytes
2) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 0.80 Pain Relevance 0.33
Atherosclerosis—P2 receptor-mediated effects on inflammatory cells
Regulation (effects) of Gene_expression (Atherosclerosis) of P2 receptor associated with inflammation and increased venous pressure under development
3) Confidence 0.19 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.30 Pain Relevance 0.34
P2 receptors may regulate VSMC phenotype and vice versa, and P2 receptor expression is markedly altered during phenotype changes [13].
Regulation (altered) of Gene_expression (expression) of P2 receptor
4) Confidence 0.13 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.92 Pain Relevance 0

General Comments

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