INT191128

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
plasma membrane (P2RX7) cytoplasm (P2RX7)
P2RX7 (Homo sapiens)
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 49 90.68 High High
Spinal cord 44 84.40 Quite High
Inflammation 21 72.64 Quite High
Cannabinoid 14 25.00 Low Low
COX2 1 25.00 Low Low
agonist 9 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Cannabinoid receptor 3 5.00 Very Low Very Low Very Low
Spinal nerve ligature 2 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 44 91.00 High High
Demyelinating Disease 52 90.68 High High
INFLAMMATION 23 72.64 Quite High
Disease 9 25.00 Low Low
Disease Progression 4 25.00 Low Low
Cancer 4 5.00 Very Low Very Low Very Low
Multiple Sclerosis 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is hypothesized that the known increase of lesion-associated extracellular ATP contributes via P2X7 activation to release IL-1 beta which in turn induces COX-2 and downstream pathogenic mediators.
Positive_regulation (activation) of P2X7 Positive_regulation (contributes) of Localization (release) of IL-1 beta
1) Confidence 0.02 Published 2006 Journal BMC Neurol Section Abstract Doc Link PMC1413551 Disease Relevance 0.71 Pain Relevance 0.34

General Comments

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