INT191137

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.22
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (H47) enzyme binding (H47) cytoplasm (H47)
H47 (Mus musculus)
Pain Link Frequency Relevance Heat
anticonvulsant 2 99.46 Very High Very High Very High
Inflammation 10 57.84 Quite High
Inflammatory response 2 45.12 Quite Low
fibrosis 23 12.60 Low Low
palliative 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 116 98.36 Very High Very High Very High
Cervical Cancer 10 97.40 Very High Very High Very High
Breast Cancer 6 81.68 Quite High
INFLAMMATION 12 57.84 Quite High
Fibrosis 28 55.36 Quite High
Frailty 3 30.56 Quite Low
Injury 2 19.84 Low Low
Necrosis 2 16.76 Low Low
Systemic Lupus Erythematosus 50 5.00 Very Low Very Low Very Low
Body Weight 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The butyrate moiety of arginine butyrate has been shown to inhibit histone deacetylase, resulting in hyperacetylation of histones H3 and H4.
H4 Binding (hyperacetylation) of
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.11 Pain Relevance 0.03
We recently demonstrated, within the context of a phase I study, that magnesium valproate when used at only slightly higher doses than those utilized as anticonvulsant, not only produces H3 and H4 histone hyperacetylation in PBMN cells, but also leads to hyperacetylation of H3 and H4 hyperacetylation and HDAC activity inhibition in primary tumors of patients with cervical cancer [104].
H4 Binding (hyperacetylation) of associated with cervical cancer, cancer and anticonvulsant
2) Confidence 0.05 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.55 Pain Relevance 0.05
We recently demonstrated, within the context of a phase I study, that magnesium valproate when used at only slightly higher doses than those utilized as anticonvulsant, not only produces H3 and H4 histone hyperacetylation in PBMN cells, but also leads to hyperacetylation of H3 and H4 hyperacetylation and HDAC activity inhibition in primary tumors of patients with cervical cancer [104].
H4 Binding (hyperacetylation) of associated with cervical cancer, cancer and anticonvulsant
3) Confidence 0.05 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.56 Pain Relevance 0.05
The model underlying H4 (mc4, only NKCC1) predicts a small decrease in [Cl?]
H4 Binding (underlying) of
4) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2613522 Disease Relevance 0 Pain Relevance 0

General Comments

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