INT191140

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.56
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (H47) enzyme binding (H47) cytoplasm (H47)
H47 (Mus musculus)
Pain Link Frequency Relevance Heat
anticonvulsant 1 98.24 Very High Very High Very High
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 58 98.36 Very High Very High Very High
Cervical Cancer 5 97.40 Very High Very High Very High
Breast Cancer 3 81.68 Quite High
Systemic Lupus Erythematosus 25 5.00 Very Low Very Low Very Low
Solid Tumor 8 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low
Hypertension 7 5.00 Very Low Very Low Very Low
Heart Rate Under Development 7 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Myelodysplastic Syndromes 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently demonstrated, within the context of a phase I study, that magnesium valproate when used at only slightly higher doses than those utilized as anticonvulsant, not only produces H3 and H4 histone hyperacetylation in PBMN cells, but also leads to hyperacetylation of H3 and H4 hyperacetylation and HDAC activity inhibition in primary tumors of patients with cervical cancer [104].
Negative_regulation (hyperacetylation) of H4 Binding (hyperacetylation) of associated with cervical cancer, cancer and anticonvulsant
1) Confidence 0.06 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.56 Pain Relevance 0.05

General Comments

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