INT191143

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atp8a1)
Anatomy Link Frequency
leukocyte 2
primary visual cortex 2
reticulum 2
Atp8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 64 97.96 Very High Very High Very High
Esophageal Cancer 1 88.72 High High
Skin Cancer 2 77.76 Quite High
Eclampsia 12 74.00 Quite High
Testicular Cancer 2 66.12 Quite High
Adhesions 2 62.40 Quite High
Infection 2 57.24 Quite High
Hepatitis 2 56.52 Quite High
Malaria 8 35.12 Quite Low
Solid Tumor 8 29.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for CTA, DNA methylation participates in regulation of the expression of the three classes of human leukocyte antigen class I antigens: HLA-A; HLA-B, and HLA-C, which are CpG-rich at their gene promoters.
Regulation (regulation) of Gene_expression (expression) of class I in leukocyte
1) Confidence 0.60 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.55 Pain Relevance 0
Activity-dependent regulation of MHC class I expression in the developing primary visual cortex of the common marmoset monkey

Background

Regulation (regulation) of Gene_expression (expression) of class I in primary visual cortex
2) Confidence 0.60 Published 2011 Journal Behav Brain Funct Section Title Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
The ERAP2 genetic diversity identified here has biological implications in terms of influencing the levels of MHC class I on the cell surface and likely downstream antigen presentation.
Spec (likely) Regulation (influencing) of Gene_expression (levels) of class I
3) Confidence 0.44 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.39 Pain Relevance 0
Here, we present genetic and functional evidence that another gene with a fundamental role in MHC class I presentation, endoplasmic reticulum aminopeptidase 2 (ERAP2), has also evolved under balancing selection and contains a variant that affects antigen presentation.
Regulation (role) of Gene_expression (presentation) of class I in reticulum
4) Confidence 0.44 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0

General Comments

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