INT191145

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.24
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atp8a1)
Anatomy Link Frequency
B cells 2
lymphocyte 2
T cell 2
Atp8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 72 97.84 Very High Very High Very High
rheumatoid arthritis 149 96.80 Very High Very High Very High
Inflammation 57 92.48 High High
Inflammatory response 4 81.32 Quite High
Arthritis 10 76.96 Quite High
Analgesic 1 76.24 Quite High
tolerance 6 71.76 Quite High
anesthesia 5 57.44 Quite High
ketamine 5 56.48 Quite High
Bioavailability 2 53.88 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 36 99.40 Very High Very High Very High
Skin Cancer 2 99.10 Very High Very High Very High
Aggression 2 97.92 Very High Very High Very High
Frailty 76 97.84 Very High Very High Very High
Rheumatoid Arthritis 149 96.80 Very High Very High Very High
Esophageal Cancer 1 96.60 Very High Very High Very High
Adhesions 2 96.48 Very High Very High Very High
Sprains And Strains 114 92.88 High High
INFLAMMATION 69 92.48 High High
Targeted Disruption 28 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the identified epitopes induced a response in all patients expressing the predicted restricting HLA class I allele.
Positive_regulation (induced) of Gene_expression (expressing) of class I
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.14 Pain Relevance 0
In RASFs, only HDAC1 mRNA and HDAC1 protein expression among class I HDACs increased through the time courses after TNF?
Positive_regulation (after) of Gene_expression (expression) of class I
2) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.10 Pain Relevance 0.44
Note that 17 of the peptides are predicted to be restricted by more than one HLA class I allele, resulting in a total of 175 unique peptides.
Positive_regulation (one) of Gene_expression (allele) of class I
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.09 Pain Relevance 0
Haplotype B homozygotes had lower levels of MHC class I expressed on the surface of B cells, suggesting that naturally occurring ERAP2 deficiency affects MHC presentation and immune response.
Positive_regulation (levels) of Gene_expression (expressed) of class I in B cells
4) Confidence 0.49 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2954825 Disease Relevance 0 Pain Relevance 0
Unlike the results of our recent study identifying WNV CD8+ T cell epitopes, where reactivity to four dominating epitopes were found in almost all patients expressing the restricting HLA class I allele [10], the CD8+ T cell epitopes identified in the present study maximally induced response in about 25% of patients bearing the appropriate HLA.
Positive_regulation (restricting) of Gene_expression (expressing) of class I in T cell
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0
Despite the complex epitope recognition pattern observed, we hypothesised that all of the newly identified WNV epitopes will induce a CTL response in all individuals carrying the restricting HLA class I allele, if the individuals were to be immunised with the epitopes.
Positive_regulation (restricting) of Gene_expression (allele) of class I
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.33 Pain Relevance 0
The complex epitope recognition pattern in the WNV infected patients showed that not all peptides that induce a CTL response in one patient do so in all patients expressing the restricting HLA class I allele.
Positive_regulation (restricting) of Gene_expression (expressing) of class I
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0
This result reflects that we started out by predicting epitopes restricted by the 12 HLA class I alleles that represent the major class I supertypes [20], but tested the predicted epitopes in all patients, regardless of whether the patients carried any of these specific 12 HLA class I supertype representative alleles or, for example, another HLA class I allele belonging to the same supertype.
Positive_regulation (belonging) of Gene_expression (allele) of class I
8) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0 Pain Relevance 0
This cDNA was chosen because class I ADH is the most efficient in the oxidation of ethanol.
Positive_regulation (because) of Gene_expression (efficient) of class I
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.24 Pain Relevance 0.12
This cDNA was chosen because class I ADH is the most efficient in the oxidation of ethanol.
Positive_regulation (because) of Gene_expression (efficient) of class I
10) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.69 Pain Relevance 0.09
Further studies that correlate ERAP2 genotype with levels of MHC class I expression in other tissues, and with the presentation and recognition of specific antigens, are needed to more clearly define the influence of ERAP2 deficiency on immune response.
Positive_regulation (levels) of Gene_expression (expression) of class I
11) Confidence 0.49 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.29 Pain Relevance 0.07
treatment; while the expressions of other class I HDACs were not elevated through the time course (0, 3, 6, 24 h) (Figure 5b).
Neg (not) Positive_regulation (elevated) of Gene_expression (expressions) of class I
12) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.39 Pain Relevance 0.19
Nie et al. showed down-regulation of HLA class I antigens in esophageal carcinoma as a common mechanism for transcriptional inactivation caused primarily by DNA hypermethylation [46], as well as in melanoma, where 5-aza-2'-deoxycytidine significantly enhances the constitutive expression of HLA class I antigens, of HLA-A1 and -A2 alleles, and of the co-stimulatory molecule, intercellular adhesion molecule-1, and lymphocyte function-associated antigen-3 [47].
Positive_regulation (enhances) of Gene_expression (expression) of class I in lymphocyte associated with skin cancer, esophageal cancer and adhesions
13) Confidence 0.45 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.80 Pain Relevance 0
High levels of expression of class I HDACs, especially HDAC2, are clinically associated with nodal spread and prognosis of gastric cancer patients [61].
Positive_regulation (levels) of Gene_expression (expression) of class I associated with stomach cancer
14) Confidence 0.45 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.81 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox