INT191147

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.03
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Dnmt1) nucleus (Dnmt1) DNA binding (Dnmt1)
protein complex (Dnmt1) transcription factor binding (Dnmt1) cytoplasm (Dnmt1)
Anatomy Link Frequency
colon 3
frontal cortex 2
lung 1
Dnmt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 2 99.00 Very High Very High Very High
gABA 1 82.56 Quite High
agonist 1 82.24 Quite High
antidepressant 1 79.40 Quite High
addiction 6 76.88 Quite High
monoamine 6 50.00 Quite Low
alcohol 1 8.16 Low Low
headache 4 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 1 98.52 Very High Very High Very High
Nicotine Addiction 171 97.76 Very High Very High Very High
Urological Neuroanatomy 1 97.20 Very High Very High Very High
Colon Cancer 5 96.16 Very High Very High Very High
Cancer 119 94.28 High High
Disease 9 87.28 High High
Anxiety Disorder 1 85.24 High High
Solid Tumor 16 81.56 Quite High
Lung Cancer 3 73.92 Quite High
Precursor Cell Lymphoblastic Leukemia-lymphoma 2 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This agent has shown an ability to inhibit DNMT1 gene expression without affecting other DNMTs and to cause demethylation with p16 re-expression in bladder and colon cancer cell lines, as well as to produce tumor growth inhibition in nude mice bearing human lung and colon xenografts [57].
Negative_regulation (inhibit) of Gene_expression (expression) of DNMT1 in colon associated with cancer and colon cancer
1) Confidence 0.45 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 1.08 Pain Relevance 0
This agent has shown an ability to inhibit DNMT1 gene expression without affecting other DNMTs and to cause demethylation with p16 re-expression in bladder and colon cancer cell lines, as well as to produce tumor growth inhibition in nude mice bearing human lung and colon xenografts [57].
Negative_regulation (inhibit) of in lung Gene_expression (expression) of DNMT1 in colon associated with cancer and colon cancer
2) Confidence 0.15 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 1.08 Pain Relevance 0
More specifically, keeping in mind that smoking is frequently abused by schizophrenia patients [49], nicotine (injected sub-cutaneously) was recently found to decrease DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in the mouse frontal cortex [50].
Negative_regulation (decrease) of Gene_expression (expression) of DNA methyltransferase 1 in frontal cortex associated with nicotine addiction, nicotine, urological neuroanatomy and schizophrenia
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775922 Disease Relevance 0.88 Pain Relevance 0.24

General Comments

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