INT191154

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 14.12
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)
Anatomy Link Frequency
tails 1
nucleus 1
face 1
HDAC9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 151 97.80 Very High Very High Very High
Osteoarthritis 41 96.68 Very High Very High Very High
rheumatoid arthritis 80 96.36 Very High Very High Very High
Inflammatory response 29 93.12 High High
Potency 4 90.24 High High
Neuritis 4 89.80 High High
agonist 26 83.20 Quite High
Hyperalgesia 17 82.52 Quite High
Spinal cord 39 76.08 Quite High
Stimulus evoked pain 2 73.80 Quite High
Disease Link Frequency Relevance Heat
Stress 28 100.00 Very High Very High Very High
Asthma 17 100.00 Very High Very High Very High
Cancer 384 99.56 Very High Very High Very High
Ovarian Cancer 17 99.56 Very High Very High Very High
Arrhythmias 2 Under Development 9 99.52 Very High Very High Very High
Hypocalcemia 5 98.84 Very High Very High Very High
Breast Cancer 106 98.76 Very High Very High Very High
Disease 115 98.40 Very High Very High Very High
Melanoma 8 98.16 Very High Very High Very High
Hypoalbuminemia 6 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Third, class IIa HDACs interact with different non-histone proteins from those that are associated with class I or class IIb HDACs [14,79], even in face of our poor understanding of the selectivity of HDACs on acetylated lysines in histone subtypes [13].


HDAC Binding (interact) of in face
1) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 0.48 Pain Relevance 0.45
Indeed, they target both HDAC Class I and Class II.
HDAC Binding (target) of
2) Confidence 0.20 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.48 Pain Relevance 0
Furthermore, a number of cytoplasmic proteins, including tubulin and HSP90, have now been shown to be acetylated by HDAC [69-73]
HDAC Binding (acetylated) of
3) Confidence 0.19 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 0.48 Pain Relevance 0
clinical trials [45].The HDAC inhibitor romidepsin has additionally been associated
HDAC inhibitor romidepsin Binding (associated) of
4) Confidence 0.18 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 2.50 Pain Relevance 0.09
Measurement of HDAC activity, class I HDACs mRNA expressions and nuclear expressions in RASFs after treatment with TNF?
HDAC Binding (activity) of
5) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.82 Pain Relevance 0.41
with a HDAC complex, providing a mechanism for specific activity of HDAC
HDAC Binding (complex) of
6) Confidence 0.14 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.06 Pain Relevance 0
The HDAC inhibitor romidepsin (FK228; depsipeptide) has also been
HDAC inhibitor romidepsin Binding (been) of
7) Confidence 0.14 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.10 Pain Relevance 0
with a HDAC complex, providing a mechanism for specific activity of HDAC
HDAC Binding (activity) of
8) Confidence 0.14 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.05 Pain Relevance 0
Another mechanism is to reverse this process by deacetylating the hyper-acetylated histones through the recruitment of HDAC-2 to the activated co-activator complex (Ito et al., 2006).
HDAC Binding (recruitment) of
9) Confidence 0.12 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 1.01 Pain Relevance 0.33
Importantly, HDAC-2 has been found to mediate the deacetylation of the GR that enables NF-?
HDAC Binding (found) of
10) Confidence 0.12 Published 2008 Journal Interdisciplinary Toxicology Section Body Doc Link PMC2993477 Disease Relevance 1.27 Pain Relevance 0.26
They found that HDAC-1 was significantly associated with improved DFS but not with the classical prognostic factors.
HDAC Binding (associated) of
11) Confidence 0.11 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.50 Pain Relevance 0
-induced transcription of MMP-1 and MMP-13 not by a physical blockade of factor binding but through a mechanism involving interaction with HDAC-containing coregulatory complexes and regulation of histone acetylation [12].


HDAC Binding (interaction) of
12) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.13 Pain Relevance 0.03
Valproic acid (VPA), which has long been used clinically for treatment of epilepsy and bipolar disorder without significant toxicity, causes hyperacetylation of the N-terminal tails of histones H3 and H4 in vitro and in vivo and inhibits HDAC activity, probably by binding to the catalytic center and thereby blocking substrate access [18,19].
HDAC Binding (binding) of in tails associated with epilepsy, toxicity and manic depressive disorder
13) Confidence 0.08 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.87 Pain Relevance 0.05
It is widely accepted that cancer development has been associated with DNA methylation deregulation and aberrant histone deacetylase (HDAC) activity, which cooperate for inducing aberrant gene silencing [100].
HDAC Binding (associated) of associated with cancer
14) Confidence 0.07 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.33 Pain Relevance 0
binding to LPL and aP2 DR1 sites via HDAC recruitment and reduced histone H3 acetylation [25, 26].
HDAC Binding (binding) of
15) Confidence 0.06 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.07 Pain Relevance 0.08
-catenin transcriptional activity by binding to Lef, forming a HDAC-Lef complex that hypoacetylates the promoter region of ?
HDAC Binding (complex) of
16) Confidence 0.06 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin by HDAC1/2 or the formation of ternary complex HDAC/?
HDAC Binding (complex) of
17) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.07 Pain Relevance 0
-catenin complex, attenuating the enzymatic activity of HDAC and allowing residual ?
HDAC Binding (activity) of
18) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin recruitment and accumulation in the nucleus, however, HDACs dissociate from Lef and form a HDAC/?
HDAC Binding (/) of in nucleus
19) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
67,68 However, a significant elevation in the oxidants can overcome both intracellular and extracellular antioxidant defenses leading to significant alterations in signaling pathways and protein function.69 The role of exogenous oxidative stress derived from cigarette smoke is highlighted by its induction of reduced GC insensitivity in experimental models and the development of relative GC insensitivity in mild or moderate asthma patients who smoke.1,55,70,71

Oxidant stress: HDAC and corepressor function

HDAC Binding (overcome) of associated with asthma and stress
20) Confidence 0.02 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.89 Pain Relevance 0.14

General Comments

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