INT191161

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.35
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CIITA) nucleus (CIITA) DNA binding (CIITA)
Anatomy Link Frequency
HGF 1
CIITA (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 8 100.00 Very High Very High Very High
Inflammation 117 50.00 Quite Low
cytokine 84 50.00 Quite Low
Inflammatory stimuli 20 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 5 100.00 Very High Very High Very High
Disease 36 99.04 Very High Very High Very High
Recurrence 18 98.72 Very High Very High Very High
Cancer 156 97.88 Very High Very High Very High
Solid Tumor 8 97.24 Very High Very High Very High
Death 13 96.12 Very High Very High Very High
Colon Cancer 20 95.92 Very High Very High Very High
Adhesions 1 94.96 High High
Sepsis 3 83.08 Quite High
Esophageal Cancer 58 82.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lower transcript levels of CIITA was detected in IFN?
Gene_expression (detected) of CIITA
1) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0 Pain Relevance 0.07
Differences in mRNA expression of IDO, HGF, COX2 and CIITA was consistently observed (Figure 5A).
Gene_expression (expression) of CIITA in HGF associated with cox2
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.08 Pain Relevance 0.10
Further, it was shown that 5-aza-2'-deoxycytidine leads to re-expression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells [48]; likewise, it has been shown that methylation-induced silencing of the class II transactivator (CIITA) leads to lack of HLA-DR induction in hematopoietic tumor cells and solid tumors such as gastric and colorectal carcinomas [49,50].


Gene_expression (expression) of CIITA associated with cancer, colon cancer, solid tumor and skin cancer
3) Confidence 0.28 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.94 Pain Relevance 0
There was no significant difference in survival between patients with NLR values of greater than or equal to 3.5 and those with an NLR of less than 3.5.
Gene_expression (values) of NLR
4) Confidence 0.26 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2819243 Disease Relevance 0.74 Pain Relevance 0
There was no significant relationship between NLR values and the probability of disease recurrence (recurrence free 2.82 IQR1.78-4.07, P = 0.82, and recurrent disease 2.79 IQR 2.12-4.28, P = 0.288).


Gene_expression (values) of NLR associated with disease and recurrence
5) Confidence 0.26 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2819243 Disease Relevance 1.12 Pain Relevance 0
There was no significant correlation between age and NLR (r = 0.094, p = 0.117, Spearman's correlation coefficient).


Gene_expression (age) of NLR
6) Confidence 0.26 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2819243 Disease Relevance 1.47 Pain Relevance 0

General Comments

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