INT191162

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DOA) plasma membrane (HLA-DOA)
Anatomy Link Frequency
leukocyte 2
HLA-DOA (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 4 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 63 98.12 Very High Very High Very High
Graft Vs Host Disease 52 81.28 Quite High
Aplastic Anemia 8 77.64 Quite High
Esophageal Cancer 1 73.68 Quite High
Testicular Cancer 2 70.60 Quite High
Skin Cancer 2 62.72 Quite High
Fever 18 52.00 Quite High
Splenomegaly 2 51.44 Quite High
Hypersplenism 2 50.40 Quite High
General Immunology 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The wider use of leukocyte-reduced blood products is likely to reduce the number of newly HLA alloimmunized patients from blood transfusions.
Negative_regulation (number) of HLA in leukocyte
1) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.38 Pain Relevance 0
The wider use of leukocyte-reduced blood products is likely to reduce the number of newly HLA alloimmunized patients from blood transfusions.
Spec (likely) Negative_regulation (reduce) of HLA in leukocyte
2) Confidence 0.12 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.38 Pain Relevance 0
HLA-E alleles were found to be in significant association with 10 CEHs (Table 3), but excluding HLA-A reduced this number.
Negative_regulation (reduced) of HLA
3) Confidence 0.05 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
In tumors, the antigen presentation pathway is commonly disrupted as a consequence of the mutations and/or deletions of one or several genes encoding components of the antigen-processing machinery, including proteasomal subunits and transporters peptides; thus, complete HLA loss is a common event in several murine and human tumors [45].
Negative_regulation (loss) of HLA associated with cancer
4) Confidence 0.01 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.48 Pain Relevance 0

General Comments

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