INT191164

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.01
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CD70) signal transduction (CD70) extracellular space (CD70)
plasma membrane (CD70) cell-cell signaling (CD70)
Anatomy Link Frequency
B cell 1
T-cells 1
CD70 (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 1 100.00 Very High Very High Very High
Migraine 178 96.48 Very High Very High Very High
cytokine 2 90.52 High High
rheumatoid arthritis 4 82.32 Quite High
Inflammation 1 22.84 Low Low
headache 4 8.76 Low Low
abatacept 3 5.56 Low Low
tolerance 8 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 97.68 Very High Very High Very High
Migraine Without Aura 46 97.12 Very High Very High Very High
Migraine With Aura 32 96.96 Very High Very High Very High
Systemic Lupus Erythematosus 25 96.80 Very High Very High Very High
Headache 150 96.48 Very High Very High Very High
Cancer 74 94.08 High High
Necrosis 5 91.88 High High
Infection 8 89.52 High High
Epstein-barr Virus 12 88.48 High High
Rheumatoid Arthritis 5 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TNFSF7 SNP, for association analysis, was selected utilizing the software SNPbrowserTM (ABI) and Ensembl Genome Browser, NCBI SNP databases.
Gene_expression (selected) of TNFSF7
1) Confidence 0.66 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577928 Disease Relevance 0.53 Pain Relevance 0.13
The results of chi-square analysis of the TNFSF7 SNP (rs1862511) are displayed in Table 4.
Gene_expression (analysis) of TNFSF7
2) Confidence 0.58 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577928 Disease Relevance 0.77 Pain Relevance 0.23
Their ligands OX40L, 4-1BBL, and CD70 are not constitutively expressed by APCs but are induced simultaneously with their receptors on T-cells, one to several days after activation (Croft 2003).
Gene_expression (expressed) of CD70 in T-cells
3) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0 Pain Relevance 0.04
In summary, these studies indicate that DNA hypomethylation and deregulated expression of molecules including LFA-1 and CD70 are fundamental for the pathogenesis of both drug-induced and idiopathic human lupus.


Gene_expression (expression) of CD70 associated with systemic lupus erythematosus
4) Confidence 0.26 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.78 Pain Relevance 0.04
A TNF super family member 7 (CD70, containing four ESTs) and a TNF receptor super family member 8 (CD30, containing four ESTs) were expressed in our cDNA library, constituting an activation pathway for B cell proliferation along with the MIF-CD74 plus CD44 complex.
Gene_expression (expressed) of CD70 in B cell associated with member 8
5) Confidence 0.25 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1522023 Disease Relevance 0.93 Pain Relevance 0.15

General Comments

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