INT191177

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.04
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
reticulum 4
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 9 100.00 Very High Very High Very High
alcohol 6 100.00 Very High Very High Very High
Inflammation 6 95.16 Very High Very High Very High
agonist 14 86.04 High High
Opioid 112 80.80 Quite High
analgesia 24 80.76 Quite High
Pain 66 79.96 Quite High
imagery 11 74.52 Quite High
Potency 3 68.36 Quite High
antagonist 14 57.00 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 20 99.80 Very High Very High Very High
Breast Cancer 204 99.76 Very High Very High Very High
Apoptosis 138 96.72 Very High Very High Very High
INFLAMMATION 8 95.16 Very High Very High Very High
Cancer 96 94.28 High High
Autoimmune Disease 1 91.80 High High
Pain 82 79.96 Quite High
Starvation 4 71.76 Quite High
Death 32 67.68 Quite High
Hyperplasia 1 59.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decursin caused a concentration-dependent decrease of ER?
Regulation (dependent) of Localization (decrease) of ER
1) Confidence 0.42 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.11
Ibandronate did not affect ER decrease induced by E2.
Regulation (affect) of Localization (decrease) of ER
2) Confidence 0.30 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0 Pain Relevance 0
The dependence of TRPM8 expression on the presence of ER?
Regulation (dependence) of Localization (presence) of ER associated with addiction
3) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.17 Pain Relevance 0.05
These results indicated that TJ-41 may enhance the antiproliferative ability of 5-FU in both ER+ and ER?
Regulation (antiproliferative) of Localization (ability) of ER
4) Confidence 0.28 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.58 Pain Relevance 0
These results indicated that TJ-41 may enhance the antiproliferative ability of 5-FU in both ER+ and ER?
Regulation (antiproliferative) of Localization (ability) of ER
5) Confidence 0.28 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.58 Pain Relevance 0
To test whether TRPM8 channels are functional at endoplasmic reticulum (ER), cells were perfused with 20 ?
Spec (whether) Regulation (functional) of Localization (reticulum) of ER in reticulum
6) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.09 Pain Relevance 0.04
In vitro studies show no effect of alcohol on the release of oxymorphone ER from the matrix; however, a volunteer study (Endo Pharmaceuticals 2007) showed that following the concomitant administration of 240 mL of 20% ethanol, the Cmax increased on average by 31%, with a wide range of variation.
Neg (no) Regulation (effect) of Localization (release) of oxymorphone ER associated with alcohol
7) Confidence 0.24 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621383 Disease Relevance 0.08 Pain Relevance 0.33
At the protein level, Nuc is constituted of 460 amino acids, including an N-terminal 25 amino acid signal peptide responsible for its initial localization to the endoplasmic reticulum (ER) [32].
Regulation (responsible) of Localization (localization) of ER in reticulum
8) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373884 Disease Relevance 0.54 Pain Relevance 0.12

General Comments

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