INT191184

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.06
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (EGFR, GRB2) endosome (EGFR, GRB2) Golgi apparatus (EGFR, GRB2)
cytoplasm (EGFR, GRB2) cell differentiation (GRB2) anatomical structure formation involved in morphogenesis (GRB2)
EGFR (Homo sapiens)
GRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 99 98.28 Very High Very High Very High
metalloproteinase 6 46.36 Quite Low
member 8 12 21.48 Low Low
imagery 18 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 85 98.42 Very High Very High Very High
Cancer 210 86.60 High High
Breast Cancer 250 82.76 Quite High
Pituitary Cancer 2 61.84 Quite High
Apoptosis 2 40.84 Quite Low
Prostate Cancer 1 14.96 Low Low
Reprotox - General 1 6 8.64 Low Low
Disease 20 5.00 Very Low Very Low Very Low
Metastasis 18 5.00 Very Low Very Low Very Low
Adhesions 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The genes encoding RECQ protein-like 5 (RECQL5), H3 histone family 3B (H3F3B) and growth factor receptor-bound protein 2 (GRB2) reside within this gene-rich region, with GRB2 shown to interact with epidermal growth factor receptor (EGFR) [53].
epidermal growth factor receptor Binding (interact) of GRB2
1) Confidence 0.35 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.08 Pain Relevance 0
The genes encoding RECQ protein-like 5 (RECQL5), H3 histone family 3B (H3F3B) and growth factor receptor-bound protein 2 (GRB2) reside within this gene-rich region, with GRB2 shown to interact with epidermal growth factor receptor (EGFR) [53].
EGFR Binding (interact) of growth factor receptor-bound protein 2
2) Confidence 0.35 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.08 Pain Relevance 0
The genes encoding RECQ protein-like 5 (RECQL5), H3 histone family 3B (H3F3B) and growth factor receptor-bound protein 2 (GRB2) reside within this gene-rich region, with GRB2 shown to interact with epidermal growth factor receptor (EGFR) [53].
epidermal growth factor receptor Binding (interact) of growth factor receptor-bound protein 2
3) Confidence 0.35 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.08 Pain Relevance 0
The genes encoding RECQ protein-like 5 (RECQL5), H3 histone family 3B (H3F3B) and growth factor receptor-bound protein 2 (GRB2) reside within this gene-rich region, with GRB2 shown to interact with epidermal growth factor receptor (EGFR) [53].
EGFR Binding (interact) of GRB2
4) Confidence 0.35 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.08 Pain Relevance 0
The genes encoding RECQ protein-like 5 (RECQL5), H3 histone family 3B (H3F3B) and growth factor receptor-bound protein 2 (GRB2) reside within this gene-rich region, with GRB2 shown to interact with epidermal growth factor receptor (EGFR) [53].
epidermal growth factor receptor Binding (interact) of GRB2
5) Confidence 0.35 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.08 Pain Relevance 0
The genes encoding RECQ protein-like 5 (RECQL5), H3 histone family 3B (H3F3B) and growth factor receptor-bound protein 2 (GRB2) reside within this gene-rich region, with GRB2 shown to interact with epidermal growth factor receptor (EGFR) [53].
EGFR Binding (interact) of GRB2
6) Confidence 0.35 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.08 Pain Relevance 0
In the ovarian cancer cell line SKOV-3, CXCL8/IL-8 was shown to induce transient phosphorylation of EGFR and its association with the adaptor molecules Shc and Grb2, suggests an important cross-talk between chemokine and growth factor pathways [39].
EGFR Binding (association) of Grb2 associated with chemokine and ovarian cancer
7) Confidence 0.10 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.57 Pain Relevance 0.10

General Comments

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