INT191194

Context Info Confidence 0.11 First Reported 2006 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 8 Disease Relevance 2.29 Pain Relevance 0.65

cytosol (MCF2) cytoskeleton (MCF2) cytoplasm (MCF2)

Anatomy Link Frequency MCF-7 6 SK-BR-3 1 MDA-MB-231 1 MCF2 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 31 99.92 Dopamine 1 91.36 Serotonin 1 90.96 Inflammation 10 78.12 cytokine 7 77.04 COX-2 inhibitor 4 50.48 COX2 2 32.92 cINOD 7 29.36 imagery 6 16.84 agonist 18 5.00

Disease Link Frequency Relevance Heat Breast Cancer 277 100.00 Reprotox - General 1 13 93.96 Hypoxia 17 90.12 INFLAMMATION 11 78.12 Cancer 76 73.08 Apoptosis 175 72.36 Stress 36 69.20 Colon Cancer 4 61.28 Metastasis 7 53.68 Pleural Effusion 2 50.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our data indicated high-level gains at the c-MYC locus in SK-BR-3 and MCF-7 (+2.84 and +1.19 log2 ratios, respectively) corresponding to previously reported change in copy number [7,37,38].

Localization (locus) of MCF-7 in MCF-7

1) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0 Pain Relevance 0

For the reversibility study, both MCF-7 and MDA-MB-231 BrCa cells were treated exactly as described above except, after synchronization of cell cycle they were incubated with 375 ?

Localization (treated) of MCF-7 in MDA-MB-231 associated with breast cancer

2) Confidence 0.05 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.49 Pain Relevance 0

Aspirin inhibited growth of human breast cancer cell line MCF-7

Localization (growth) of MCF-7 in MCF-7 associated with aspirin and breast cancer

3) Confidence 0.05 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1569375 Disease Relevance 0.81 Pain Relevance 0.56

Because MCF-7 is a model for determining estrogenic or antiestrogenic effects, we can conclude that the benefical effects of black cohosh in alleviating postmenopausal complaints might be rather due to central nervous action via dopamine, serotonin or ?

Localization (Because) of MCF-7 in MCF-7 associated with dopamine and serotonin

4) Confidence 0.04 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.16 Pain Relevance 0.09

Our data indicated high-level gains at the c-MYC locus in SK-BR-3 and MCF-7 (+2.84 and +1.19 log2 ratios, respectively) corresponding to previously reported change in copy number [7,37,38].

Localization (locus) of MCF-7 in SK-BR-3

5) Confidence 0.04 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0 Pain Relevance 0

For the reversibility study, both MCF-7 and MDA-MB-231 BrCa cells were treated exactly as described above except, after synchronization of cell cycle they were incubated with 375 ?

Localization (treated) of MCF-7 in MCF-7 associated with breast cancer

6) Confidence 0.02 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.49 Pain Relevance 0

was predominantly localized in the nucleus in MCF-7 cells grown in PRF-IMEM medium without serum and insulin for 48 hours.

Localization (localized) of MCF-7 in MCF-7

7) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.18 Pain Relevance 0

nuclear translocation in MCF-7 cells.

Localization (translocation) of MCF-7 in MCF-7

8) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.17 Pain Relevance 0

General Comments

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