INT1912

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Context Info
Confidence 0.78
First Reported 1978
Last Reported 2011
Negated 32
Speculated 55
Reported most in Abstract
Documents 1152
Total Number 1207
Disease Relevance 453.25
Pain Relevance 739.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
DRG 93
neurons 84
plasma 67
nerve 45
spinal cord 38
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 9572 100.00 Very High Very High Very High
qutenza 3003 100.00 Very High Very High Very High
Pain 2684 100.00 Very High Very High Very High
Inflammation 2010 100.00 Very High Very High Very High
Spinal cord 1917 100.00 Very High Very High Very High
substance P 1823 100.00 Very High Very High Very High
dorsal root ganglion 1703 100.00 Very High Very High Very High
Neuropeptide 1316 100.00 Very High Very High Very High
antagonist 956 100.00 Very High Very High Very High
nociceptor 843 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3260 100.00 Very High Very High Very High
Pain 2401 100.00 Very High Very High Very High
INFLAMMATION 2031 100.00 Very High Very High Very High
Nociception 1464 100.00 Very High Very High Very High
Depression 287 100.00 Very High Very High Very High
Disease 285 100.00 Very High Very High Very High
Natriuresis 89 100.00 Very High Very High Very High
Recurrence 68 100.00 Very High Very High Very High
Repression 36 100.00 Very High Very High Very High
Neuroendocrine Cancer 12 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in the synthesis and release of calcitonin gene-related peptide in two-kidney, one-clip hypertensive rats.
Gene_expression (synthesis) of calcitonin gene-related peptide in kidney associated with hypertension and calcitonin gene-related peptide
1) Confidence 0.78 Published 2003 Journal Regul. Pept. Section Title Doc Link 12832107 Disease Relevance 0.25 Pain Relevance 0.64
Treatment with capsaicin, a single injection or a second injection, prevented the increased in the expression of CGRP mRNA in DRG.
Gene_expression (expression) of CGRP mRNA in DRG associated with qutenza and calcitonin gene-related peptide
2) Confidence 0.78 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12832107 Disease Relevance 0.23 Pain Relevance 0.91
The objective of the present study was to determine the effect of early pregnancy on the sensitivity to, and endogenous production of calcitonin gene-related peptide (CGRP).
Gene_expression (production) of calcitonin gene-related peptide associated with calcitonin gene-related peptide
3) Confidence 0.78 Published 2003 Journal J. Vasc. Res. Section Abstract Doc Link 12891003 Disease Relevance 0 Pain Relevance 0.29
The objective of the present study was to determine the effect of early pregnancy on the sensitivity to, and endogenous production of calcitonin gene-related peptide (CGRP).
Gene_expression (production) of CGRP associated with calcitonin gene-related peptide
4) Confidence 0.78 Published 2003 Journal J. Vasc. Res. Section Abstract Doc Link 12891003 Disease Relevance 0 Pain Relevance 0.29
These data show that relief of clinical pain after shock wave application may result from reduced CGRP expression in DRG neurons.
Gene_expression (expression) of CGRP in neurons associated with dorsal root ganglion, pain, shock and calcitonin gene-related peptide
5) Confidence 0.78 Published 2003 Journal Auton Neurosci Section Abstract Doc Link 12963418 Disease Relevance 1.41 Pain Relevance 0.77
The purpose of this study is to clarify the effects of 17beta-estradiol and the Japanese herbal medicine Keishi-bukuryo-gan on the release and synthesis of calcitonin gene-related peptide (CGRP) in ovariectomized (OVX) rats.
Gene_expression (synthesis) of calcitonin gene-related peptide associated with calcitonin gene-related peptide
6) Confidence 0.78 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501156 Disease Relevance 0 Pain Relevance 0.45
The purpose of this study is to clarify the effects of 17beta-estradiol and the Japanese herbal medicine Keishi-bukuryo-gan on the release and synthesis of calcitonin gene-related peptide (CGRP) in ovariectomized (OVX) rats.
Gene_expression (synthesis) of CGRP associated with calcitonin gene-related peptide
7) Confidence 0.78 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14501156 Disease Relevance 0 Pain Relevance 0.45
Effects of 17 beta-estradiol and the Japanese herbal medicine Keishi-bukuryo-gan on the release and synthesis of calcitonin gene-related peptide in ovariectomized rats.
Gene_expression (synthesis) of calcitonin gene-related peptide associated with calcitonin gene-related peptide
8) Confidence 0.78 Published 2003 Journal J. Pharmacol. Sci. Section Title Doc Link 14501156 Disease Relevance 0 Pain Relevance 0.49
These hormones may regulate the synthesis and receptor expression of calcitonin gene-related peptide (CGRP), which mediates neurogenic dural vasodilatation and is implicated in migraine pathogenesis.
Gene_expression (expression) of CGRP associated with migraine, increased venous pressure under development and calcitonin gene-related peptide
9) Confidence 0.78 Published 2007 Journal Headache Section Abstract Doc Link 17300362 Disease Relevance 0.36 Pain Relevance 0.32
These hormones may regulate the synthesis and receptor expression of calcitonin gene-related peptide (CGRP), which mediates neurogenic dural vasodilatation and is implicated in migraine pathogenesis.
Gene_expression (expression) of calcitonin gene-related peptide associated with migraine, increased venous pressure under development and calcitonin gene-related peptide
10) Confidence 0.78 Published 2007 Journal Headache Section Abstract Doc Link 17300362 Disease Relevance 0.36 Pain Relevance 0.32
The expression of calcitonin gene-related peptide (CGRP) in dorsal root ganglion (DRG) neurons innervating the knee using immunohistochemistry was examined in the three groups at their peak time point on the treadmill.
Spec (examined) Gene_expression (expression) of CGRP in knee
11) Confidence 0.78 Published 2007 Journal Osteoarthr. Cartil. Section Body Doc Link 17466542 Disease Relevance 0.26 Pain Relevance 0
C7 spinal cord tissue was analyzed by immunohistochemistry for substance P and calcitonin gene-related peptide (CGRP) expression on days 1 and 7 for each injury; densitometry quantified immunoreactivity in lamina I of the ipsilateral dorsal horn.
Spec (analyzed) Gene_expression (expression) of calcitonin gene-related peptide in lamina
12) Confidence 0.78 Published 2005 Journal Spine Section Body Doc Link 16284585 Disease Relevance 0.06 Pain Relevance 0
For individual rats, substance P was significantly (P < 0.001) correlated with CGRP expression for both injuries.
Gene_expression (expression) of CGRP
13) Confidence 0.78 Published 2005 Journal Spine Section Body Doc Link 16284585 Disease Relevance 0 Pain Relevance 0
C7 spinal cord tissue was analyzed by immunohistochemistry for substance P and calcitonin gene-related peptide (CGRP) expression on days 1 and 7 for each injury; densitometry quantified immunoreactivity in lamina I of the ipsilateral dorsal horn.
Spec (analyzed) Gene_expression (expression) of CGRP in lamina
14) Confidence 0.78 Published 2005 Journal Spine Section Body Doc Link 16284585 Disease Relevance 0.06 Pain Relevance 0
The aim of this study was to investigate the possible influence of low-energy ESWT on the expression of the transmitters substance P (SP) and calcitonin gene-related peptide (CGRP) in the lumbar spinal cord of the rat.
Gene_expression (expression) of CGRP in spinal cord associated with spinal cord, calcitonin gene-related peptide and substance p
15) Confidence 0.78 Published 2002 Journal J Orthop Sci Section Abstract Doc Link 11819140 Disease Relevance 0.46 Pain Relevance 0.68
The aim of this study was to investigate the possible influence of low-energy ESWT on the expression of the transmitters substance P (SP) and calcitonin gene-related peptide (CGRP) in the lumbar spinal cord of the rat.
Gene_expression (expression) of calcitonin gene-related peptide in spinal cord associated with spinal cord, calcitonin gene-related peptide and substance p
16) Confidence 0.78 Published 2002 Journal J Orthop Sci Section Abstract Doc Link 11819140 Disease Relevance 0.46 Pain Relevance 0.68
Following injection of the bulbocavernosus/levator ani with extracts from castrated rats, the level of CGRP expression and the number of SNB motoneurons with alpha-CGRP message were increased.
Gene_expression (expression) of CGRP in motoneurons associated with calcitonin gene-related peptide
17) Confidence 0.78 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.22 Pain Relevance 0.60
Paralysis of the bulbocavernosus/levator ani with a local anesthetic increased the number of SNB motoneurons expressing alpha-CGRP mRNA and CGRP immunoreactive neurons.
Gene_expression (expressing) of CGRP in levator ani associated with paralysis, calcitonin gene-related peptide and local anesthetic
18) Confidence 0.78 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.27 Pain Relevance 0.54
In the present study, we tested the hypothesis that gonadal steroids influence CGRP expression in SNB motoneurons through their effects on the bulbocavernosus and levator ani muscles.
Gene_expression (expression) of CGRP in levator ani associated with calcitonin gene-related peptide
19) Confidence 0.78 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.08 Pain Relevance 0.41
Since both the SNB motoneurons and their target muscles, the bulbocavernosus and the levator ani, are steroid sensitive, gonadal steroids may act at either site to regulate CGRP expression.
Gene_expression (expression) of CGRP in gonadal associated with calcitonin gene-related peptide
20) Confidence 0.78 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0.07 Pain Relevance 0.37

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