INT191211

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.96
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (GRB2) endosome (GRB2) anatomical structure formation involved in morphogenesis (GRB2)
aging (GRB2) Golgi apparatus (GRB2) protein complex (GRB2)
GRB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 2 99.74 Very High Very High Very High
Serotonin 2 98.92 Very High Very High Very High
GABA receptor 2 98.50 Very High Very High Very High
Glutamate receptor 6 98.00 Very High Very High Very High
Neurotransmitter 4 97.42 Very High Very High Very High
metalloproteinase 3 46.36 Quite Low
member 8 4 21.48 Low Low
imagery 6 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 110 94.80 High High
Cancer 88 90.36 High High
Schizophrenia 100 87.60 High High
Recurrence 4 83.84 Quite High
Advanced Or Metastatic Breast Cancer 11 72.00 Quite High
Endometriosis (extended) 3 63.64 Quite High
Myopia 22 50.00 Quite Low
Disease 49 46.08 Quite Low
Hyperopia 9 14.96 Low Low
Reprotox - General 1 2 8.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The genes encoding RECQ protein-like 5 (RECQL5), H3 histone family 3B (H3F3B) and growth factor receptor-bound protein 2 (GRB2) reside within this gene-rich region, with GRB2 shown to interact with epidermal growth factor receptor (EGFR) [53].
Gene_expression (reside) of GRB2
1) Confidence 0.62 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.08 Pain Relevance 0
The genes encoding RECQ protein-like 5 (RECQL5), H3 histone family 3B (H3F3B) and growth factor receptor-bound protein 2 (GRB2) reside within this gene-rich region, with GRB2 shown to interact with epidermal growth factor receptor (EGFR) [53].
Gene_expression (reside) of growth factor receptor-bound protein 2
2) Confidence 0.62 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.08 Pain Relevance 0
Among the four well-known neurotransmitter pathways (glutamate receptor signaling, GABA receptor signaling, serotonin receptor signaling and dopamine receptor signaling), GRB2 appeared in all the four pathways and HSPA5 in three pathways, and the interaction between GRB2 and HSPA5 appeared in three pathways.
Gene_expression (appeared) of GRB2 associated with neurotransmitter, dopamine receptor, gaba receptor, glutamate receptor and serotonin
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.28 Pain Relevance 0.32
GRB2, SPTBN1, ABCC10, and OPBP2 were differentially expressed in response to +6.9D and ?
Gene_expression (expressed) of GRB2
4) Confidence 0.53 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0
Overexpression of transmembrane peptide growth factor receptors, such as the epidermal growth factor receptor (EGFR) or the human epidermal receptor 2 (HER2) has been associated with poor prognosis and resistance to hormonal therapy [1,2].
Gene_expression (Overexpression) of epidermal receptor 2
5) Confidence 0.05 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.51 Pain Relevance 0

General Comments

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