| in lung tissue.
Lungs with a paralyzed vasculature that were isolated and perfused with whole blood 12 h after CLP developed fulminant edema before 120 minutes had elapsed.
Correspondingly, in lungs isolated from healthy rats, in which the vasculature had been paralyzed, injection of ET-1 into the pulmonary artery induced pulmonary edema within 60 minutes.
The non-selective ET-1 receptor blocker tezosentan prevents both CLP- and ET-1-induced pulmonary edema in isolated blood perfused rat lungs.
Tezosentan also precludes CLP-induced activation of PKC?