INT191214

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Cotl1, Prkcg) cytoplasm (Cotl1, Prkcg) enzyme binding (Cotl1)
response to stress (Prkcg) cytosol (Prkcg) cytoskeleton (Cotl1)
Anatomy Link Frequency
plasma 1
Cotl1 (Rattus norvegicus)
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 6 81.68 Quite High
antagonist 4 26.76 Quite Low
Versed 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Rate Under Development 22 98.64 Very High Very High Very High
Adult Respiratory Distress Syndrome 26 97.36 Very High Very High Very High
Paralysis 16 97.28 Very High Very High Very High
Pressure And Volume Under Development 14 92.10 High High
Lung Injury 4 49.96 Quite Low
Sepsis 4 49.16 Quite Low
Body Weight 10 5.00 Very Low Very Low Very Low
Weight Gain 6 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in lung tissue.

• Lungs with a paralyzed vasculature that were isolated and perfused with whole blood 12 h after CLP developed fulminant edema before 120 minutes had elapsed. • Correspondingly, in lungs isolated from healthy rats, in which the vasculature had been paralyzed, injection of ET-1 into the pulmonary artery induced pulmonary edema within 60 minutes. • The non-selective ET-1 receptor blocker tezosentan prevents both CLP- and ET-1-induced pulmonary edema in isolated blood perfused rat lungs. • Tezosentan also precludes CLP-induced activation of PKC?

CLP Positive_regulation (activation) of PKC associated with heart rate under development, pressure and volume under development and paralysis
1) Confidence 0.10 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.67 Pain Relevance 0.04
Key messages

• In rats, CLP increases the plasma concentration of ET-1 and activates PKC?

CLP Positive_regulation (activates) of PKC in plasma
2) Confidence 0.09 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.68 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox