INT191221

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 24.24
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Amigo2) plasma membrane (Amigo2) nucleus (Amigo2)
Anatomy Link Frequency
lung 4
plasma 1
neutrophil 1
Amigo2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 51 99.40 Very High Very High Very High
antagonist 24 99.34 Very High Very High Very High
Inflammation 159 99.08 Very High Very High Very High
cva 45 95.04 Very High Very High Very High
cytokine 75 94.00 High High
Inflammatory response 40 93.00 High High
Kinase C 15 73.28 Quite High
Inflammatory stimuli 4 72.68 Quite High
Inflammatory mediators 7 71.72 Quite High
Catecholamine 92 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 579 100.00 Very High Very High Very High
Sepsis 98 99.98 Very High Very High Very High
Pancreatitis 18 99.98 Very High Very High Very High
Lung Injury 263 99.92 Very High Very High Very High
Cv General 4 Under Development 1 99.84 Very High Very High Very High
Cv Unclassified Under Development 53 99.40 Very High Very High Very High
Pneumonia 93 99.08 Very High Very High Very High
Injury 227 98.88 Very High Very High Very High
Death 14 98.76 Very High Very High Very High
Hemorrhage 24 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We present a novel culture model of sepsis-induced ALI where the septic insult is applied in vivo, prior to cell isolation.
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome and sepsis
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.75 Pain Relevance 0.08
We recently reported that in sheep an apparent association exists between endotoxin-induced ALI and activation of PKC?
Positive_regulation (activation) of ALI associated with adult respiratory distress syndrome
2) Confidence 0.09 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.58 Pain Relevance 0.04
ALI can be induced by a broad spectrum of insults, including large tidal volume ventilation, pneumonia, ischemia, smoke inhalation, pulmonary hemorrhage, and sepsis [5], [6].
Positive_regulation (induced) of ALI associated with ischemia, pneumonia, adult respiratory distress syndrome, cva and sepsis
3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 1.71 Pain Relevance 0.10
2-adrenoceptor blocker, (RX 821002), or the competitive aldosterone receptor antagonist (spironolactone) in adrenal-intact and adrenalectomized animals immediately after induction of IC-ALI.
Positive_regulation (induction) of IC-ALI associated with antagonist and adult respiratory distress syndrome
4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 1.25 Pain Relevance 0.27
To exclude that these results were unique to immune complex-induced ALI, lung injury was also induced in rats by intra-tracheal administration of LPS and subjected to analysis for vascular leakage, MPO content, BAL fluid cytokines measurements and histological analysis.
Positive_regulation (induced) of ALI in lung associated with lung injury, urological neuroanatomy, adult respiratory distress syndrome and cytokine
5) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 1.18 Pain Relevance 0.20
We recently reported that in sheep an apparent association exists between endotoxin-induced ALI and activation of PKC?
Positive_regulation (activation) of ALI associated with adult respiratory distress syndrome
6) Confidence 0.06 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.58 Pain Relevance 0.04
We recently reported experiments in sheep in which the ET-1 receptor antagonist tezosentan attenuates endotoxin-induced ALI, as evaluated by a decline in extravascular lung water [14].
Positive_regulation (induced) of ALI in lung associated with antagonist and adult respiratory distress syndrome
7) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.54 Pain Relevance 0.09
In patients diagnosed with ALI, derangement of pulmonary function was exacerbated by elevated plasma concentrations of ET-1, whereas clinical improvement was associated with a significant fall in concentrations of ET-1, indicating that ET-1 could act as a marker of ALI [26-28].
Positive_regulation (marker) of ALI in plasma associated with adult respiratory distress syndrome
8) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.65 Pain Relevance 0
The present study demonstrates a difference in PKC involvement between ET-1 and CLP-induced ALI.
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
9) Confidence 0.05 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.61 Pain Relevance 0.03
HTS did not reduce the severity of evolving oleic acid induced ALI.
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
10) Confidence 0.04 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.63 Pain Relevance 0.24
Hypertonic saline reduced alveolar neutrophil infiltration in both evolving and resolving oleic induced ALI.
Positive_regulation (induced) of ALI in neutrophil associated with adult respiratory distress syndrome
11) Confidence 0.04 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.01 Pain Relevance 0.13
The importance of EC cell death has been further supported by data observed in animal models inducing ALI after lipopolysaccharide injection [8,9].
Positive_regulation (inducing) of ALI associated with adult respiratory distress syndrome and death
12) Confidence 0.03 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 1.95 Pain Relevance 0.08
Series 2 – Resolving OA induced ALI
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
13) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 0.39 Pain Relevance 0.07
Therefore, while HTS reduced indices of pulmonary inflammation, it not attenuate the severity of oleic acid induced ALI.


Neg (not) Positive_regulation (induced) of ALI associated with inflammation, adult respiratory distress syndrome and pneumonia
14) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.36 Pain Relevance 0.16
However, the potential for HTS to modulate oleic acid-induced ALI has not been assessed

Effect of HTS on evolving ALI

Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
15) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.67 Pain Relevance 0.24
HTS did enhance the resolution of oleic acid induced ALI.
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
16) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.29 Pain Relevance 0.16
Specifically, we hypothesized that HTS would modulate the severity of OA induced ALI, reducing lung injury and/or enhancing resolution of ALI.
Positive_regulation (induced) of ALI in lung associated with lung injury and adult respiratory distress syndrome
17) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 1.78 Pain Relevance 0.10
In conclusion, we report for the first time that hypertonic saline enhances the resolution of oleic induced ALI.
Positive_regulation (induced) of ALI associated with adult respiratory distress syndrome
18) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 0.99 Pain Relevance 0
The therapeutic potential of HTS is demonstrated by its efficacy when used following initiation of the injury process, in both ischemia-reperfusion and pancreatitis induced ALI [1,3].
Positive_regulation (induced) of ALI associated with ischemia, pancreatitis, injury and adult respiratory distress syndrome
19) Confidence 0.03 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2467400 Disease Relevance 2.08 Pain Relevance 0.16
Mura and colleagues [20] estimated the VEGF expression in lung tissue and its concentration in plasma and the bronchoalveolar lavage (BAL) fluid in an extrapulmonary model of ALI induced by intestinal ischemia/reperfusion (I/R) in rats [20].
Positive_regulation (induced) of ALI in lung associated with cv general 4 under development, ischemia and adult respiratory distress syndrome
20) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 1.26 Pain Relevance 0.05

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