INT191285

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
adipocytes 4
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 204 99.76 Very High Very High Very High
Disease Progression 2 86.72 High High
Disease 76 85.60 High High
Cognitive Disorder 80 85.52 High High
Disorder Of Lipid Metabolism 88 78.68 Quite High
Atherosclerosis 28 77.24 Quite High
Cardiovascular Disease 16 69.00 Quite High
Stress 24 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Dementia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our investigation clearly shows that apoA-I effectively increases the release of cholesterol, as well as largely increasing the secretion of apoE by mature adipocytes (figures 1 and 5).
Positive_regulation (increasing) of Localization (secretion) of apoE in adipocytes associated with obesity
1) Confidence 0.66 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.51 Pain Relevance 0
ApoA-I increases apoE secretion with minimal effect upon apoE gene expression
Positive_regulation (upon) of Localization (secretion) of apoE
2) Confidence 0.48 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.38 Pain Relevance 0
In addition, no data is currently available on the signalling pathways involved in the apoA-I induced secretion of apoE.
Positive_regulation (induced) of Localization (secretion) of apoE
3) Confidence 0.48 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.33 Pain Relevance 0
We demonstrate that apoA-I induces a strong increase in cholesterol release and apoE secretion from adipocytes, whereas it has no transcriptional effect on ABCA1 or apoE genes.
Positive_regulation (increase) of Localization (secretion) of apoE in adipocytes associated with obesity
4) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2917427 Disease Relevance 0.90 Pain Relevance 0
The three groups were homogeneous with respect to age [70.8 (5.4), 70.7 (6.8) and 72.0 (7.3) for low, intermediate and high MMSE scores, respectively], but differed regarding the presence of at least one APOE ?
Positive_regulation (least) of Localization (one) of APOE
5) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1420275 Disease Relevance 0.47 Pain Relevance 0
The three groups were homogeneous with respect to age [70.8 (5.4), 70.7 (6.8) and 72.0 (7.3) for low, intermediate and high MMSE scores, respectively], but differed regarding the presence of at least one APOE ?
Positive_regulation (regarding) of Localization (presence) of APOE
6) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1420275 Disease Relevance 0.48 Pain Relevance 0

General Comments

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