INT19132

Context Info Confidence 0.75 First Reported 1991 Last Reported 2010 Negated 2 Speculated 2 Reported most in Body Documents 83 Total Number 86 Disease Relevance 34.31 Pain Relevance 10.17

mitochondrion (CYP27A1) small molecule metabolic process (CYP27A1)

Anatomy Link Frequency monocytes 5 macrophages 3 joint 3 knee 3 cartilage 2 CYP27A1 (Homo sapiens)

Pain Link Frequency Relevance Heat COX-2 inhibitor 234 100.00 Osteoarthritis 1327 99.64 spinal inflammation 362 99.60 cytokine 214 99.56 rheumatoid arthritis 426 98.48 conotoxin 3 96.80 Bile 2 96.32 Analgesic 35 95.80 metalloproteinase 43 94.16 depression 20 91.60

Disease Link Frequency Relevance Heat Hypercalcemia 517 99.84 Metastasis 654 99.68 Osteoarthritis 1261 99.64 Low Back Pain 379 99.60 Disease 454 99.16 Breast Cancer 243 98.84 Chronic Hepatitis 138 98.80 Rheumatoid Arthritis 516 98.48 Van Bogaert's Disease 10 98.28 Osteoporosis 411 97.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Transfection of mutant cDNAs into cultured cells results in the synthesis of immunoreactive sterol 27-hydroxylase protein with greatly diminished enzyme activity.

Gene_expression (synthesis) of sterol 27-hydroxylase

1) Confidence 0.75 Published 1991 Journal J. Biol. Chem. Section Abstract Doc Link 2019602 Disease Relevance 1.01 Pain Relevance 0.29

Adachi and Fukuyo [28] confirmed that wild and cultured G. toxicus produce precursors of CTXs (known as gambiertoxins) [29].

Gene_expression (produce) of CTX

2) Confidence 0.75 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.71 Pain Relevance 0

In 2001, the total synthesis of CTX3C was achieved by Hirama et al. [139], based on highly convergent and efficient strategy for the assembly of structural fragments.

Gene_expression (synthesis) of CTX

3) Confidence 0.75 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.15 Pain Relevance 0

D CTX levels.

Gene_expression (levels) of CTX

4) Confidence 0.66 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.43 Pain Relevance 0

L CTX values below the mean of nonmetastasised controls (NC-patients), 52% of these patients had ?

Gene_expression (values) of CTX associated with metastasis

5) Confidence 0.66 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 1.00 Pain Relevance 0

L CTX levels alone showed a significant elevation in 58% of the metastatic patients, which probably reflects an increased bone turnover (increased resorption + increased formation) as an important feature in the majority of bone metastatic patients.

Gene_expression (levels) of CTX

6) Confidence 0.66 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.20 Pain Relevance 0

L CTX is reflected in the CTX ratios, providing an index of bone collagen half-life [9].

Gene_expression (reflected) of CTX

7) Confidence 0.66 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.31 Pain Relevance 0

L CTX and the NC+ patients had 2.2-fold higher levels of ?

Gene_expression (had) of CTX

8) Confidence 0.66 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.18 Pain Relevance 0

D CTX ratio showed the highest average increases in accordance with the ability of the ?

Gene_expression (ratio) of CTX

9) Confidence 0.66 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.17 Pain Relevance 0

L CTX levels and the ?

Gene_expression (levels) of CTX

10) Confidence 0.66 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.16 Pain Relevance 0

L CTX levels, and a 2.2-fold elevation was seen in NC+ patients, indicating that the more severe condition in the HC+ patients is reflected by the ?

Gene_expression (levels) of CTX

11) Confidence 0.66 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.39 Pain Relevance 0

This assay enabled the detection of P-CTXs and C-CTXs in the very low range of 0.078–5.00 ng/mL (i.e., 7.8 × 10?

Gene_expression (detection) of CTX

12) Confidence 0.65 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0 Pain Relevance 0

This assay enabled the detection of P-CTXs and C-CTXs in the very low range of 0.078–5.00 ng/mL (i.e., 7.8 × 10?

Gene_expression (detection) of CTX

13) Confidence 0.65 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0 Pain Relevance 0

Cerebrotendinous xanthomatosis is an inherited autosomal recessive disease caused by a mutation in the gene for the sterol 27-hydroxylase enzyme, which determines the accumulation of plasmatic cholestanol in various tissues.

Gene_expression (enzyme) of sterol 27-hydroxylase associated with van bogaert's disease and disease

14) Confidence 0.65 Published 2009 Journal Rev Med Chil Section Abstract Doc Link 19746285 Disease Relevance 0.99 Pain Relevance 0.08

Levels of both CTX-II and CTX-I, as markers of cartilage and bone degradation respectively, decreased by approximately 50% in the treatment group compared with baseline, and CTX-II levels were restored to premenopausal levels.

Gene_expression (Levels) of CTX-I in cartilage

15) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.46 Pain Relevance 0.17

Levels of both CTX-II and CTX-I, as markers of cartilage and bone degradation respectively, decreased by approximately 50% in the treatment group compared with baseline, and CTX-II levels were restored to premenopausal levels.

Gene_expression (Levels) of CTX-II in cartilage

16) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.46 Pain Relevance 0.17

Such OA may be referred to as a systemic, metabolic form of OA [1], which is supported by our finding that bone resorption, indicated by CTX-I levels, was higher in women than in men.

Gene_expression (levels) of CTX-I associated with hypercalcemia and osteoarthritis

17) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 0.90 Pain Relevance 0.25

L CTX form and the older ?

Gene_expression (form) of CTX

18) Confidence 0.58 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.88 Pain Relevance 0

Among the CTX ratios, the ?

Gene_expression (ratios) of CTX

19) Confidence 0.58 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.31 Pain Relevance 0

L CTX form and the ?

Gene_expression (form) of CTX

20) Confidence 0.58 Published 2003 Journal Breast Cancer Res Section Body Doc Link PMC165019 Disease Relevance 0.22 Pain Relevance 0

General Comments

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