INT191328

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mdk) extracellular region (Mdk)
Anatomy Link Frequency
brain 2
Mir327 (Mus musculus)
Mdk (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 8 84.16 Quite High
Eae 32 82.40 Quite High
cocaine 118 79.00 Quite High
Potency 4 76.56 Quite High
Nucleus accumbens 32 46.16 Quite Low
Glutamate receptor 4 42.88 Quite Low
Dopamine 16 41.92 Quite Low
Ventral tegmentum 26 40.24 Quite Low
amygdala 8 38.20 Quite Low
Neuropeptide 2 17.80 Low Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low
Recurrence 4 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we have investigated the role of ERK activation in the behavioral sensitization induced by repeated administration of psychostimulants in mice, using SL327, a brain-penetrating selective inhibitor of MAP-kinase/ERK kinase (MEK), the enzyme that selectively activates ERK.


SL327 Negative_regulation (inhibitor) of MEK in brain
1) Confidence 0.00 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.18
We first evaluated the efficacy of SL327 to inhibit MEK in the brain by counting the number of neurons immunopositive for diphospho-ERK (P-ERK) in several brain areas involved in the addictive effects of psychostimulants [18] (Table 1).
SL327 Negative_regulation (inhibit) of MEK in brain
2) Confidence 0.00 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.10

General Comments

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