INT191329

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
brain 1
Mir327 (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 84.16 Quite High
Eae 16 81.44 Quite High
cocaine 59 76.72 Quite High
Nucleus accumbens 16 5.00 Very Low Very Low Very Low
Ventral tegmentum 13 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low
Recurrence 2 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we have investigated the role of ERK activation in the behavioral sensitization induced by repeated administration of psychostimulants in mice, using SL327, a brain-penetrating selective inhibitor of MAP-kinase/ERK kinase (MEK), the enzyme that selectively activates ERK.


SL327 Negative_regulation (inhibitor) of ERK in brain
1) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.18

General Comments

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