INT191342

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 3.50
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IDO1) small molecule metabolic process (IDO1) oxidoreductase activity (IDO1)
cellular nitrogen compound metabolic process (IDO1)
Anatomy Link Frequency
NK cells 2
HGF 2
T cells 2
IDO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 16 100.00 Very High Very High Very High
Pain 64 99.28 Very High Very High Very High
cytokine 173 93.20 High High
Inflammation 202 92.80 High High
dorsal root ganglion 2 91.20 High High
Inflammatory stimuli 40 90.40 High High
visual analogue scale 20 89.52 High High
Arthritis 4 82.16 Quite High
Pain score 14 62.96 Quite High
Spinal cord 4 61.48 Quite High
Disease Link Frequency Relevance Heat
Bladder Disease 68 100.00 Very High Very High Very High
Overactive Bladder 52 100.00 Very High Very High Very High
INFLAMMATION 243 92.80 High High
Graft Vs Host Disease 20 90.28 High High
Ganglion Cysts 4 90.24 High High
Incontinence 8 89.60 High High
Pain 48 88.72 High High
Arthritis 4 82.16 Quite High
Injury 12 79.88 Quite High
Frailty 4 61.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression levels of known MSC immune-modulatory molecules such as IDO, HGF and COX2 generated PGE2 differed in culture supernatants of both the MSCs (Figure 5).
Positive_regulation (generated) of Gene_expression (Expression) of IDO in HGF associated with cox2
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.37 Pain Relevance 0.32
(produced by T cells and natural killer [NK] cells) to stimulate IDO production by MPCs, which in turn inhibits the proliferation of activated T or NK cells. [13].
Positive_regulation (stimulate) of Gene_expression (production) of IDO in NK cells
2) Confidence 0.33 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0 Pain Relevance 0
inducible IDO activity was higher in IFN?
Positive_regulation (higher) of Gene_expression (activity) of IDO
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.06 Pain Relevance 0.09
inducible IDO activity was higher in IFN?
Positive_regulation (inducible) of Gene_expression (activity) of IDO
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.06 Pain Relevance 0.09
induced IDO production by MSCs was shown to be the key player in immuno-suppression of T cells [34].
Positive_regulation (induced) of Gene_expression (production) of IDO in T cells
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 1.15 Pain Relevance 0.45
The myelin stained fibres also showed a two-fold increase in the PBS and IDO groups, but this was not statistically significant (PBS, P = 0.143, IDO, P = 0.076; Fig 3d).
Positive_regulation (increase) of Gene_expression (groups) of IDO associated with bladder disease
6) Confidence 0.13 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.81 Pain Relevance 0.22
IDO : Idiopathic detrusor overactivity
Positive_regulation (overactivity) of Gene_expression (overactivity) of IDO associated with overactive bladder
7) Confidence 0.13 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 1.06 Pain Relevance 0.59

General Comments

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