INT191347

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.60
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
nucleus (Shc1) cytoplasm (Shc1)
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 88 97.16 Very High Very High Very High
cerebral cortex 20 88.24 High High
anesthesia 2 85.16 High High
Calcium channel 2 75.36 Quite High
tetrodotoxin 1 16.92 Low Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 44 98.48 Very High Very High Very High
Cv Unclassified Under Development 86 97.16 Very High Very High Very High
Coronary Artery Disease 92 87.28 High High
Stress 96 85.68 High High
Body Weight 2 77.68 Quite High
Atherosclerosis 24 77.12 Quite High
Death 8 75.56 Quite High
Disease 8 70.72 Quite High
Repression 69 64.44 Quite High
Diabetes Mellitus 16 60.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For all these reasons we did not study the Met/Val variant in our cohorts, since we were looking for variants that would affect particularly the p66Shc gene.


Regulation (affect) of p66Shc
1) Confidence 0.27 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.56 Pain Relevance 0
The p66Shc promoter, positioned in the first intron of the Shc locus, contains a relative high frequency of CpG dinucleotides whose methylation regulates the transcriptional activity of p66Shc promoter [8].
Regulation (regulates) of p66Shc
2) Confidence 0.27 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.93 Pain Relevance 0
Finally, this Met/Val amino acid variant is present in all 3 isoform of the Shc gene, thus suggesting that this polymorphism is unlikely to specifically affect the function of p66Shc and not of p46Shc and p52Shc.
Regulation (affect) of p66Shc
3) Confidence 0.27 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.61 Pain Relevance 0
Finally, this Met/Val amino acid variant is present in all 3 isoform of the Shc gene, thus suggesting that this polymorphism is unlikely to specifically affect the function of p66Shc and not of p46Shc and p52Shc.
Regulation (affect) of p52Shc
4) Confidence 0.23 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 0.62 Pain Relevance 0
Sham control (SHC and SHC3d) animals were prepared in the same way as for the R30 and R3d animals, respectively, without carotid occlusion.
Regulation (control) of SHC
5) Confidence 0.21 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.41 Pain Relevance 0.33
Depolarization also frequently regulates splicing in genes encoding signaling and scaffold proteins (Shc1, D4Ertd22e, Samhd1, Adcyap1r1, Nf2, and Spna2).
Regulation (regulates) of Shc1
6) Confidence 0.15 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.06 Pain Relevance 0.04
spots when compared with the SHC control (Fig. 2, R30).
Regulation (control) of SHC
7) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.39 Pain Relevance 0.23

General Comments

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