INT191354

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.07
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC4, Shc1) cytoplasm (HDAC4, Shc1) cytosol (HDAC4)
mitochondrion (Shc1) aging (Shc1) plasma membrane (Shc1)
Anatomy Link Frequency
lymphocytes 3
HDAC4 (Homo sapiens)
Shc1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 4 84.56 Quite High
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 6 90.56 High High
Stress 10 88.64 High High
Cv Unclassified Under Development 4 84.56 Quite High
Death 2 83.08 Quite High
Apoptosis 1 68.76 Quite High
Targeted Disruption 2 60.92 Quite High
Aging 11 50.00 Quite Low
Coronary Artery Disease 23 36.16 Quite Low
Disease 2 24.24 Low Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regard, it has been reported that histone deacetylase inhibitors and demethylating agents restore p66Shc expression in human peripheral blood lymphocytes (PBL) that normally do not express this isoform [8].
Negative_regulation (inhibitors) of histone deacetylase in lymphocytes Positive_regulation (restore) of Gene_expression (expression) of p66Shc in lymphocytes
1) Confidence 0.02 Published 2006 Journal BMC Genet Section Body Doc Link PMC1420326 Disease Relevance 1.07 Pain Relevance 0.16

General Comments

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