INT19145

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Context Info
Confidence 0.00
First Reported 1991
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 11
Disease Relevance 0.29
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Edf1) methyltransferase activity (Edf1) nucleolus (Edf1)
nucleus (Edf1) cytoplasm (Edf1)
Anatomy Link Frequency
sympathetic 3
blood 2
MBF 2
Edf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 40 99.78 Very High Very High Very High
isoflurane 14 99.04 Very High Very High Very High
anesthesia 7 97.16 Very High Very High Very High
halothane 10 96.76 Very High Very High Very High
Acupuncture 10 75.00 Quite High
ischemia 4 72.08 Quite High
Disease Link Frequency Relevance Heat
Pathologic Constriction 2 88.08 High High
Coronary Artery Disease 4 72.96 Quite High
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the ischemic area, rMBF was reduced depending on the inspired concentration of each anesthetic agent and transmural maldistribution of blood flow was not observed with any anesthetic agent.
Negative_regulation (reduced) of rMBF in blood
1) Confidence 0.00 Published 1991 Journal Masui Section Abstract Doc Link 2020097 Disease Relevance 0.15 Pain Relevance 0.64
As the inspired concentration of each anesthetic is increased, rMBF decreased significantly and rMBF/rate-pressure-product (RPP) ratio increased in normal area.
Negative_regulation (decreased) of rMBF
2) Confidence 0.00 Published 1991 Journal Masui Section Abstract Doc Link 2020097 Disease Relevance 0.14 Pain Relevance 0.59
In conclusion, EAS to a hindpaw at a stimulus strength sufficient to excite group III and IV afferent fibers, particularly group IV afferent fibers, can produce a reflex decrease in MBF via a reflex activation of muscle sympathetic activity, although this decrease in MBF is overridden by an increase in MBF caused passively by a reflex MAP pressor response elicited by a reflex increase, at least in splanchnic sympathetic activity.
Negative_regulation (decrease) of MBF in sympathetic
3) Confidence 0.38 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10189107 Disease Relevance 0 Pain Relevance 0.04
The increased response of MBF at 10.0 mA was followed by a small decrease in MBF.
Negative_regulation (decrease) of MBF in MBF
4) Confidence 0.38 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10189107 Disease Relevance 0 Pain Relevance 0.07
The decrease in MBF was abolished following further severance of the bilateral lumbar sympathetic trunks (LSTs).
Negative_regulation (decrease) of MBF in sympathetic
5) Confidence 0.38 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10189107 Disease Relevance 0 Pain Relevance 0.07
In conclusion, EAS to a hindpaw at a stimulus strength sufficient to excite group III and IV afferent fibers, particularly group IV afferent fibers, can produce a reflex decrease in MBF via a reflex activation of muscle sympathetic activity, although this decrease in MBF is overridden by an increase in MBF caused passively by a reflex MAP pressor response elicited by a reflex increase, at least in splanchnic sympathetic activity.
Negative_regulation (decrease) of MBF in sympathetic
6) Confidence 0.38 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10189107 Disease Relevance 0 Pain Relevance 0.04
Following severance of the bilateral splanchnic nerves, EAS at 10.0 mA induced only a slight increase in MAP and a decrease in MBF.
Negative_regulation (decrease) of MBF in MBF
7) Confidence 0.38 Published 1999 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10189107 Disease Relevance 0 Pain Relevance 0.07
We found that ablation of sensory neurons by capsaicin pretreatment (100 mg/kg over 3 days) reduced by around 45% the mucosal blood flow (MBF), as measured by laser Doppler flowmetry, in normal fed and refed rats, while by 15% only in fasted animals.
Negative_regulation (reduced) of MBF in blood associated with qutenza
8) Confidence 0.35 Published 1995 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8527816 Disease Relevance 0 Pain Relevance 0.42
This last group of animals had significant decrease in the MBF even in control conditions as compared to that recorded in fed animals.
Negative_regulation (decrease) of MBF
9) Confidence 0.35 Published 1995 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8527816 Disease Relevance 0 Pain Relevance 0.41
Treatment with NG-nitro-L-arginine (L-NNA; 2 x 20 mg/kg daily s.c.), a selective blocker of NO synthase, significantly suppressed the MBF in all three groups of animals tested but this suppression was less pronounced when compared to capsaicin pretreatment.
Negative_regulation (suppressed) of MBF associated with qutenza
10) Confidence 0.35 Published 1995 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8527816 Disease Relevance 0 Pain Relevance 0.44
The combination of capsaicin and L-NNA decreased the MBF significantly and the inhibition was stronger than the effect of each substance given alone.
Negative_regulation (decreased) of MBF associated with qutenza
11) Confidence 0.35 Published 1995 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8527816 Disease Relevance 0 Pain Relevance 0.48

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