INT19146

Context Info Confidence 0.36 First Reported 1981 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 19 Total Number 19 Disease Relevance 5.34 Pain Relevance 6.73

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2) extracellular space (Apoa2) extracellular region (Apoa2) cellular_component (Apoa2)

Anatomy Link Frequency plasma 2 LHA 2 PAG 1 RVLM 1 GALT 1 Apoa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat noradrenaline 3 100.00 Morphine 8 99.52 Rostral ventrolateral medulla 4 99.30 bradykinin 1 99.20 Glutamate 5 99.06 long-term potentiation 1 98.84 substance P 1 98.72 anesthesia 21 98.50 Clonidine 13 98.42 halothane 8 98.28

Disease Link Frequency Relevance Heat Urological Neuroanatomy 8 100.00 Shock 1 99.50 Body Weight 2 99.08 Ovarian Cancer 6 98.80 Pressure And Volume Under Development 2 98.64 Hypertension 9 98.50 Pressure Volume 2 Under Development 11 98.36 Endometriosis 99 97.76 Cancer 7 96.88 Disease 10 96.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The result suggests that central AII directly inhibits RSNA via AII specific receptors.

Negative_regulation (inhibits) of AII

1) Confidence 0.36 Published 1989 Journal J. UOEH Section Abstract Doc Link 2609034 Disease Relevance 0 Pain Relevance 0.12

The involvement of AII in the mediation of EtOH intoxication effects on the aerial righting reflex supports results of our previous studies on the effects of EtOH on open field behavior, AII impairment of the retention of an inhibitory shock avoidance response, and AII inhibition of hippocampal granule cell long-term potentiation, all of which can be blocked by losartan.

Negative_regulation (inhibition) of AII in hippocampal granule cell associated with shock, long-term potentiation and poisoning

2) Confidence 0.36 Published 1996 Journal Alcohol Section Abstract Doc Link 8734844 Disease Relevance 0.25 Pain Relevance 0.25

After all doses of prazosin (40, 80 and 120 nmol), AII induced bradycardic responses, but only the 80 and 120 nmol doses of prazosin reduced the pressor responses to AII.

Negative_regulation (reduced) of AII

3) Confidence 0.35 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2171000 Disease Relevance 0 Pain Relevance 0.49

In the present investigation we studied the effect of the injection of clonidine, phenylephrine, prazosin or yohimbine into the lateral hypothalamic area (LHA) on the water intake induced by water deprivation or central angiotensin II (AII) in rats.

Negative_regulation (deprivation) of AII in LHA associated with clonidine

4) Confidence 0.31 Published 1990 Journal Brain Res. Section Abstract Doc Link 2224504 Disease Relevance 0 Pain Relevance 0.55

In contrast, during 2.2% halothane anesthesia the increase in plasma ANP produced by volume loading was greater and the decrease in AII was abolished.

Negative_regulation (decrease) of AII in plasma associated with anesthesia and halothane

5) Confidence 0.30 Published 1989 Journal Anesth. Analg. Section Abstract Doc Link 2521280 Disease Relevance 0.24 Pain Relevance 0.67

A 30% blood volume load in conscious rats produced a transient increase in blood pressure and central venous pressure, a threefold rise in plasma ANP, and a decrease in AII.

Negative_regulation (decrease) of AII in plasma associated with pressure and volume under development

6) Confidence 0.30 Published 1989 Journal Anesth. Analg. Section Abstract Doc Link 2521280 Disease Relevance 0.25 Pain Relevance 0.66

PB diminished the effect of NA and AII in all vascular beds studied, while C-U only depressed renal and splanchnic reactivity.

Negative_regulation (diminished) of AII associated with noradrenaline

7) Confidence 0.29 Published 1987 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3435208 Disease Relevance 0.09 Pain Relevance 0.23

The spontaneously hypertensive rat, either pithed or anesthetized with urethane, responds to intravenous injections of angiotensin I (A1) and angiotensin II (AII) with pressor responses.

Negative_regulation (injections) of AII associated with hypertension

8) Confidence 0.26 Published 1981 Journal J Pharmacol Methods Section Abstract Doc Link 6273658 Disease Relevance 0.10 Pain Relevance 0

Intra-hippocampal inhibition of protein kinase AII attenuates morphine-induced conditioned place preference.

Negative_regulation (inhibition) of kinase AII associated with morphine

9) Confidence 0.25 Published 2006 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 17174386 Disease Relevance 0 Pain Relevance 0.64

Goumenou et al. [35], by microsatellite analysis, demonstrated that loss of heterozygosity on p16(Ink4), GALT, and p53, as well as on APOA2, a region frequently lost in ovarian cancer, occurs in endometriosis, even in stage II of the disease.

Negative_regulation (loss) of APOA2 in GALT associated with endometriosis, ovarian cancer and disease

10) Confidence 0.23 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 1.68 Pain Relevance 0.46

Injection of clonidine or phenylephrine into the LHA reduced the water intake produced by both water deprivation and i.c.v. injection of AII.

Negative_regulation (deprivation) of AII in LHA associated with clonidine

11) Confidence 0.20 Published 1990 Journal Brain Res. Section Abstract Doc Link 2224504 Disease Relevance 0 Pain Relevance 0.55

These results demonstrate that i.v. converting enzyme inhibitor reduces the release of GLU in the RVLM, which was specifically caused by reducing circulating AII, without any effect on GLY release, thus resulting in the reduction of blood pressure with minimal effect on the heart rate.

Negative_regulation (reducing) of AII in RVLM associated with rostral ventrolateral medulla and glutamate

12) Confidence 0.19 Published 1994 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 7982287 Disease Relevance 0.24 Pain Relevance 0.41

Due to fast breakdown of All in the circulatory system, all observed vagus stimulation effects were completely recovered within 1 h after injection. (3) Plasma concentration of AII was recorded with a highly specific radioimmunoassay: 10 min after AII injection (non-pressor range), plasma concentration was clearly higher than physiological levels in all experiments with 10 microg AII/kg at least. (4) Treatment with propranolol (beta-adrenoceptor blocker, 1 mg/kg body weight) did not reduce the vagus effects alone, but decreased the modulatory AII effects.

Neg (not) Negative_regulation (decreased) of AII in circulatory system associated with body weight

13) Confidence 0.15 Published 1998 Journal Regul. Pept. Section Abstract Doc Link 9712176 Disease Relevance 0.17 Pain Relevance 0

The effect of AII from the ventrolateral PAG was inhibited by the previous local administration of saralasin, a non-selective angiotensin receptor antagonist.

Negative_regulation (inhibited) of AII in PAG associated with antagonist and urological neuroanatomy

14) Confidence 0.12 Published 2003 Journal Brain Res. Section Abstract Doc Link 12711094 Disease Relevance 0.62 Pain Relevance 0.69

In conclusion, a small decrease of the activity of nigrostriatal dopaminergic system caused by the decrease of AII and/or increase of bradykinin, substance P, enkephalins and neurotensin in brain resulting from ACE inhibition is postulated.

Negative_regulation (decrease) of AII in brain associated with enkephalin, bradykinin and substance p

15) Confidence 0.10 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2279685 Disease Relevance 0.16 Pain Relevance 0.20

Suppression of AII by ACE-inhibition reduces efferent vascular tone and thus filtration rate.

Negative_regulation (Suppression) of AII

16) Confidence 0.10 Published 1985 Journal Klin. Wochenschr. Section Abstract Doc Link 2997540 Disease Relevance 0.47 Pain Relevance 0.08

NaCl was not suppressed by the blockade of ganglionic transmission, alpha-adrenergic receptor, AVP or angiotensin II (AII).

Negative_regulation (blockade) of AII

17) Confidence 0.10 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2505699 Disease Relevance 0.22 Pain Relevance 0.09

Intracerebroventricular (i.c.v.) injection of leumorphin through an implanted cannula into the lateral ventricle of rats dose-dependently inhibited water intake induced by water deprivation, angiotensin II (AII) and carbachol.

Negative_regulation (deprivation) of AII in lateral ventricle associated with intracerebroventricular

18) Confidence 0.09 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3796789 Disease Relevance 0 Pain Relevance 0.58

In order to study the mechanism in which the kidney may be involved, SANA during SNP-induced hypotension was measured before and after intravenous infusion of angiotensin II competitive inhibitor, [Sar1, Ile8] angiotensin II (SI-AII), (n = 5).

Negative_regulation (inhibitor) of SI-AII in kidney associated with pressure volume 2 under development

19) Confidence 0.04 Published 1991 Journal Masui Section Abstract Doc Link 2020101 Disease Relevance 0.86 Pain Relevance 0.06

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