INT191460

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.46
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (REV1) nucleus (REV1) intracellular (REV1)
REV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 61 99.20 Very High Very High Very High
Crohn's disease 1 67.60 Quite High
Gabapentin 1 54.88 Quite High
Potency 17 5.00 Very Low Very Low Very Low
sodium channel 14 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
anticonvulsant 10 5.00 Very Low Very Low Very Low
lidocaine 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
antidepressant 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 326 97.32 Very High Very High Very High
Contagious Ecthyma 4 93.48 High High
Telangiectasia 4 88.72 High High
Death 2 82.00 Quite High
Ataxia 1 71.52 Quite High
Infection 62 68.76 Quite High
Disease 20 66.96 Quite High
Herpes Simplex Virus 1 36.96 Quite Low
Cold Sores 6 35.20 Quite Low
Hepatitis B Virus Infection 5 34.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tat/rev shRNA target sequence is located on both gag-pol and on rev mRNAs so we reasoned that inserting a synonymous mutation in rev that would alter the shRNA target on the lentiviral helper plasmid, but would not change the Rev ORF, might increase titers.
Localization (located) of rev associated with contagious ecthyma
1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.15 Pain Relevance 0
The tat/rev shRNA target sequence is located on both gag-pol and on rev mRNAs so we reasoned that inserting a synonymous mutation in rev that would alter the shRNA target on the lentiviral helper plasmid, but would not change the Rev ORF, might increase titers.
Localization (located) of rev associated with contagious ecthyma
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.15 Pain Relevance 0
Comments on the interpretation of these properties (Rev, ?
Localization (interpretation) of Rev
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004914 Disease Relevance 0 Pain Relevance 0.21
By a similar rationale, Hauber et al. [29] used knowledge about the HIV Rev protein to identify a novel antiviral agent: Rev uses the eukaryotic initiation factor 5A (eIF-5a) as a cofactor for the nuclear export of unspliced viral RNAs containing the Rev-responsive element.
Localization (export) of Rev-responsive associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.03 Published 2006 Journal Genome Biol Section Body Doc Link PMC1431708 Disease Relevance 1.16 Pain Relevance 0.03

General Comments

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