INT191477

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.98
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1d) signal transducer activity (Htr1d)
Anatomy Link Frequency
nociceptors 1
Htr1d (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Periaqueductal grey 110 99.90 Very High Very High Very High
Analgesic 16 99.32 Very High Very High Very High
Trigeminal ganglion neurons 60 98.96 Very High Very High Very High
GABAergic 54 98.80 Very High Very High Very High
Sumatriptan 94 98.38 Very High Very High Very High
nociceptor 4 98.20 Very High Very High Very High
Migraine 26 98.04 Very High Very High Very High
fluoxetine 12 97.72 Very High Very High Very High
Triptan 50 94.76 High High
depression 2 94.20 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 110 99.90 Very High Very High Very High
Headache 28 98.04 Very High Very High Very High
Depression 2 94.20 High High
Pain 26 92.36 High High
Ganglion Cysts 16 80.80 Quite High
Nociception 6 66.60 Quite High
INFLAMMATION 4 63.96 Quite High
Neuropathic Pain 2 60.48 Quite High
Cluster Headache 16 55.88 Quite High
Bordatella Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present cellular findings indicate that the anti-migraine drug sumatriptan activates, or disinhibits descending analgesic pathways from within the PAG via activation of 5-HT1B and 5-HT1D receptors.
Positive_regulation (activation) of 5-HT1D associated with sumatriptan, periaqueductal grey, analgesic and migraine
1) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 1.03 Pain Relevance 1.69
M) all produced a significant increase in the ratio of evoked IPSC2/IPSC1 (Figure 1c, e, p = 0.003, 0.04, 0.03, n = 21, 7, 14).

5-HT1A, 5-HT1B and 5-HT1D receptor activation inhibits GABAergic synaptic transmission

Positive_regulation (increase) of 5-HT1D associated with gabaergic
2) Confidence 0.20 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.32 Pain Relevance 0.59
Fourth, synaptic transmission from TGNs to central trigeminovascular neurons is blocked by activation of presynaptic 5HT1B/1D receptors on central terminals of meningeal nociceptors [7].
Positive_regulation (activation) of 5HT1B/1D in nociceptors associated with nociceptor and trigeminal ganglion neurons
3) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.39 Pain Relevance 1.23
This paper clarified that zolmitriptan could inhibit HVA Ca2+ channels by activating 5HT1B/1D receptor coupled to Gi/o pathway.


Positive_regulation (activating) of 5HT1B/1D
4) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.23 Pain Relevance 0.72

General Comments

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