INT191478

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Context Info
Confidence 0.25
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
lateral 2
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 35 99.78 Very High Very High Very High
agonist 7 99.08 Very High Very High Very High
antagonist 5 99.00 Very High Very High Very High
Triptan 16 98.30 Very High Very High Very High
Sciatic nerve 31 92.80 High High
c fibre 74 87.84 High High
withdrawal 10 82.72 Quite High
Spinal cord 7 61.04 Quite High
central sensitization 18 50.00 Quite Low
Trigeminal ganglion neurons 30 35.16 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 9 91.44 High High
Neuropathic Pain 9 74.40 Quite High
Injury 9 73.44 Quite High
Cluster Headache 8 50.00 Quite Low
Headache 4 7.60 Low Low
Bordatella Infection 3 6.16 Low Low
Pain 17 5.00 Very Low Very Low Very Low
Hyperalgesia 9 5.00 Very Low Very Low Very Low
Nervous System Injury 9 5.00 Very Low Very Low Very Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly this also extended to the lateral dorsal horn where the increase in Iba-1 immunoreactivity seen in the adult that is associated with the surgical incision was also absent in both the stimulated and sham groups (Fig. 6B).
Negative_regulation (absent) of Positive_regulation (increase) of Iba-1 in lateral associated with dorsal horn
1) Confidence 0.25 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0.31 Pain Relevance 0.66
Since triptans are known to act as 5-HT1B/1D agonists, we examined whether or not the zolmitriptan-induced inhibition on IBa could be blocked by a 5-HT1B/1D receptor antagonist, GR127935.
Negative_regulation (blocked) of Positive_regulation (induced) of IBa associated with antagonist, agonist and triptan
2) Confidence 0.08 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0 Pain Relevance 0.29

General Comments

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