INT191480

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Context Info
Confidence 0.02
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Htr3a, Ca2) cytosol (Ca2) extracellular space (Ca2)
lyase activity (Ca2) plasma membrane (Htr3a) response to stress (Ca2)
Anatomy Link Frequency
neuronal 1
Htr3a (Rattus norvegicus)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 84.72 Quite High
5HT 1 71.76 Quite High
Sumatriptan 4 69.12 Quite High
Trigeminal ganglion neurons 30 62.80 Quite High
Triptan 16 51.04 Quite High
Neuropeptide 2 45.52 Quite Low
trigeminal ganglion 5 26.56 Quite Low
nociceptor 2 10.88 Low Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vibrio Infection 1 72.48 Quite High
Cluster Headache 8 50.24 Quite High
Nociception 1 38.88 Quite Low
Ganglion Cysts 8 25.68 Quite Low
Pain 4 5.00 Very Low Very Low Very Low
Headache 4 5.00 Very Low Very Low Very Low
Bordatella Infection 3 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation might be compatible with the previous reports that an increase in intracellular Ca2+ level by 5HT1 receptor is associated with activation of Gi/Go protein coupled pathway [13,14] and that the modulation of neuronal voltage-gated Ca2+ channel is mediated by receptors coupled to PTX-sensitive G proteins [15,16].
5HT1 receptor Positive_regulation (increase) of Ca2 in neuronal
1) Confidence 0.02 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434723 Disease Relevance 0.12 Pain Relevance 0.23

General Comments

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