INT191493

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.35
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP3) signal transduction (NLRP3) plasma membrane (AGTR1)
cytoplasm (NLRP3) signal transducer activity (AGTR1)
Anatomy Link Frequency
leukocyte 1
AGTR1 (Homo sapiens)
NLRP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 96.24 Very High Very High Very High
Inflammation 55 84.56 Quite High
cytokine 15 83.80 Quite High
agonist 22 50.00 Quite Low
Angina 5 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 92 99.68 Very High Very High Very High
Adhesions 13 95.92 Very High Very High Very High
Renal Disease 1 93.40 High High
Cv General 4 Under Development 3 91.92 High High
Pressure And Volume Under Development 24 90.56 High High
Atherosclerosis 17 89.80 High High
INFLAMMATION 61 84.56 Quite High
Weight Gain 4 67.60 Quite High
Stress 30 66.48 Quite High
Diabetes Mellitus 43 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through AT1 receptor, AII causes vasoconstriction and prothrombogenic, oxidizing and antifybrinolitic effects, and also favors adhesion molecule expression and leukocyte adhesion.
AT1 Binding (receptor) of AII in leukocyte associated with increased venous pressure under development and adhesions
1) Confidence 0.03 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.27 Pain Relevance 0.32
AT1-R, leaving AII to interact with the relatively beneficial AT2-R.
AT1 Binding (interact) of AII
2) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 1.08 Pain Relevance 0.08

General Comments

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