INT191527

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 8.65
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NLRP3) signal transduction (NLRP3) cytoplasm (NLRP3)
NLRP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 5 98.46 Very High Very High Very High
Inflammation 123 97.52 Very High Very High Very High
cytokine 46 96.48 Very High Very High Very High
Inflammatory response 9 87.52 High High
Herpes zoster virus 1 84.92 Quite High
antagonist 18 84.00 Quite High
anakinra 20 82.40 Quite High
agonist 50 82.16 Quite High
vagus nerve 2 75.12 Quite High
Inflammatory mediators 5 31.68 Quite Low
Disease Link Frequency Relevance Heat
Leukostasis 16 99.80 Very High Very High Very High
Disease 66 98.48 Very High Very High Very High
Crystal Associated Disease 6 98.44 Very High Very High Very High
Adhesions 16 97.96 Very High Very High Very High
INFLAMMATION 134 97.52 Very High Very High Very High
Diabetes Mellitus 73 96.80 Very High Very High Very High
Syndrome 117 95.92 Very High Very High Very High
Diabetic Retinopathy 94 93.36 High High
Exanthema 7 92.40 High High
Arthralgia 5 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
as the principal consequence of CIAS1 mutations leading to the manifestation of the clinical disease, the CASP1 mutation appears to exert its pro-inflammatory effect by engaging RIP2, resulting in excessive activation of NF-?
Positive_regulation (leading) of Gene_expression (mutations) of CIAS1 associated with inflammation and disease
1) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.13 Pain Relevance 0.14
However, as compared to the 6 h samples, their mRNA expression level recovered 24 h after irradiation in such a way that the expression levels of Nalp3 and Nalp10 became significantly higher than those measured from non-exposed control cells (Figure 4B).
Positive_regulation (higher) of Gene_expression (expression) of Nalp3
2) Confidence 0.47 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.09 Pain Relevance 0
A constitutively active form of mutated NALP3/cryopyrin, which promotes IL-1?
Positive_regulation (mutated) of Gene_expression (/) of NALP3
3) Confidence 0.22 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.02 Pain Relevance 0.26
, interleukins IL-1 and IL-6, adhesion molecules and chemokines, that cause inhibition of ONS-III activity and with that NO production, and favoring AII synthesis and activity [26-30].
Positive_regulation (favoring) of Gene_expression (synthesis) of AII associated with chemokine and adhesions
4) Confidence 0.08 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.54 Pain Relevance 0.37
and increased retinal expression and production of AII, AT1-R, and AT2-R [30].
Positive_regulation (increased) of Gene_expression (expression) of AII
5) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 2.43 Pain Relevance 0.19
and increased retinal expression and production of AII, AT1-R, and AT2-R [30].
Positive_regulation (increased) of Gene_expression (production) of AII
6) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396446 Disease Relevance 2.43 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox