INT19155

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Context Info
Confidence 0.47
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 6.41
Pain Relevance 10.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
neuronal 2
hippocampus 2
brain 1
fibroblast 1
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 1686 100.00 Very High Very High Very High
antagonist 332 100.00 Very High Very High Very High
Dopamine 158 100.00 Very High Very High Very High
agonist 486 99.96 Very High Very High Very High
B1 receptor 1 99.96 Very High Very High Very High
nMDA receptor 102 99.90 Very High Very High Very High
depression 68 99.60 Very High Very High Very High
Hippocampus 239 99.34 Very High Very High Very High
Glutamate 239 99.32 Very High Very High Very High
Antinociceptive 12 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 11 100.00 Very High Very High Very High
Sleep Disorders 6 99.92 Very High Very High Very High
Neurological Disease 85 99.86 Very High Very High Very High
Depression 69 99.60 Very High Very High Very High
Sprains And Strains 4 99.50 Very High Very High Very High
Disease 103 98.68 Very High Very High Very High
Ataxia 34 98.20 Very High Very High Very High
Hyperalgesia 1 97.32 Very High Very High Very High
Neuropathic Pain 1 96.64 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 1 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A1R binding was evaluated by incubating the brain section from WT and A1R Hz animals with increasing (0.2–10 nM) concentrations of A1R antagonist [3H]1,3-dipropyl-8-cyclopentylxanthine ([3H]DPCPX) as described in [50].
A1R Binding (binding) of in brain associated with antagonist
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0.06 Pain Relevance 0.15
Interaction between A1Rs and NMDA receptors
A1R Binding (Interaction) of associated with nmda receptor
2) Confidence 0.47 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.07 Pain Relevance 0.62
There is increasing evidence that the functional interaction of A1Rs with other neuronal receptors may contribute to fine tuning in synaptic transmission, and A1R agonists may represent a useful therapeutic approach for the treatment of some neurological disorders by regulating homeostasis in transmitter systems.
A1R Binding (interaction) of in neuronal associated with neurological disease and agonist
3) Confidence 0.47 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.52 Pain Relevance 0.46
The purpose of this study was to examine factors that may contribute to, or interact with, A1R-mediated depression of preBötC rhythmogenesis including effects of A1R activation on synaptic transmission and membrane properties.
A1R Binding (interact) of associated with depression
4) Confidence 0.42 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.10 Pain Relevance 0.30
The results confirmed an antagonistic interaction between A1Rs and D1Rs that had already been observed by Ferré et al. [51] in behavioral studies using reserpinized mice and rabbits.
A1R Binding (interaction) of
5) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.21 Pain Relevance 0.52
Ginés et al. [50] described the formation of functionally interacting heteromeric complexes between dopamine D1 receptors (D1Rs) and A1Rs in mouse fibroblast Ltk?
A1R Binding (complexes) of in fibroblast associated with dopamine
6) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.24 Pain Relevance 0.55
As in the hippocampus, A2AR stimulation decreased the affinity of A1Rs for agonists.
A1R Binding (affinity) of in hippocampus associated with agonist and hippocampus
7) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.07 Pain Relevance 0.55
Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor.
adenosine A1 receptor Binding (lacking) of associated with adenocard
8) Confidence 0.36 Published 2003 Journal J Sleep Res Section Title Doc Link 14633239 Disease Relevance 0.72 Pain Relevance 0.44
This is evidence for potential interaction between A1Rs and Y1Rs that may modulate long-term desensitization of A1Rs during pathophysiological situations.
A1R Binding (interaction) of
9) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.22 Pain Relevance 0.22
Functional interaction between A1Rs and P2X receptors
A1R Binding (interaction) of
10) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.44 Pain Relevance 0.29
The authors pointed out that Cl-IB-MECA binds to A1Rs even at low nanomolar concentrations.
A1R Binding (binds) of
11) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.08 Pain Relevance 0.30
Interaction between A1Rs and GABAA receptors
A1R Binding (Interaction) of
12) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0 Pain Relevance 0.62
NMDA receptors and A1Rs interact to downregulate glutamate release presynaptically in pyramidal cells of the cingulate cortex [35], neurons of the hippocampus [100], and striatal neurons [84].
A1R Binding (interact) of in hippocampus associated with glutamate, pyramidal cell, nmda receptor and hippocampus
13) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.06 Pain Relevance 0.61
Mice deficient for adenosine A1 receptors (A1AR) lack tubuloglomerular feedback (TGF).
A1AR Binding (deficient) of associated with adenocard
14) Confidence 0.34 Published 2004 Journal Pflugers Arch. Section Abstract Doc Link 14767772 Disease Relevance 0 Pain Relevance 0.18
The researchers first asked whether ischemic preconditioning protects the kidneys of mice strains that lack the genes for individual adenosine receptors (A1AR?
A1AR Binding (individual) of associated with adenocard and sprains and strains
15) Confidence 0.33 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504049 Disease Relevance 1.03 Pain Relevance 0.60
The antinociceptive effect of intrathecally administered adenosine analogs in mice correlates with the affinity for the A1-adenosine receptor.
A1-adenosine Binding (affinity) of associated with adenocard and antinociceptive
16) Confidence 0.27 Published 1991 Journal Neurosci. Lett. Section Title Doc Link 2020383 Disease Relevance 0 Pain Relevance 1.03
Interaction of angiotensin II and adenosine A1 and A2A receptor ligands on the writhing test in mice.
adenosine A1 Binding (Interaction) of associated with adenocard
17) Confidence 0.26 Published 2002 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 11900765 Disease Relevance 0 Pain Relevance 0.65
Experimental evidence has shown that the bradykinin B1 receptor (BKB1-R) is involved in the development of type 1 diabetes and found to be upregulated alongside the disease.
BKB1-R Binding (found) of associated with diabetes mellitus, b1 receptor and disease
18) Confidence 0.21 Published 2010 Journal Neuropeptides Section Abstract Doc Link 20092893 Disease Relevance 1.63 Pain Relevance 0.43
The binding for selective A1R agonists was decreased while the A1R antagonist binding remained unaffected.
A1R Binding (binding) of associated with antagonist and agonist
19) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.08 Pain Relevance 0.48
The binding for selective A1R agonists was decreased while the A1R antagonist binding remained unaffected.
A1R Binding (binding) of associated with antagonist and agonist
20) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.08 Pain Relevance 0.43

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