INT191565

Context Info Confidence 0.68 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0.06

endosome (Htr4) plasma membrane (Htr4) cytoplasm (Htr4) signal transducer activity (Htr4)

Anatomy Link Frequency large intestines 1 Htr4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat nud 1 66.08 agonist 10 61.56 Bile 25 5.00 antagonist 8 5.00 spastic colon 6 5.00 Action potential 4 5.00 Serotonin 4 5.00 tetrodotoxin 2 5.00 Cholecystokinin 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Dyspepsia 1 66.08 Gallbladder Disease 3 18.68 Gastrointestinal Disease 1 14.72 Cardiovascular Disease 1 10.64 Disease 1 8.24 Gallstones 6 5.00 Functional Bowel Disorder 3 5.00 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 3 5.00 Arrhythmia Under Development 1 5.00 Increased Venous Pressure Under Development 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The 5-HT4 receptors, localized to cholinergic nerves, are involved in the contraction of smooth muscle from canine small and large intestines [43,44] and human large intestines [43].

Localization (localized) of 5-HT4 in large intestines

1) Confidence 0.68 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1434748 Disease Relevance 0.07 Pain Relevance 0.06

General Comments

This test has worked.