INT19157

Context Info Confidence 0.71 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.39 Pain Relevance 2.18

transmembrane transporter activity (SLC22A6) plasma membrane (SLC22A6) protein complex (SLC22A6) transmembrane transport (SLC22A6)

Anatomy Link Frequency plasma 1 proximal 1 oocytes 1 SLC22A6 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 19 99.16 methotrexate 20 99.02 anesthesia 3 98.72 isoflurane 5 93.28

Disease Link Frequency Relevance Heat INFLAMMATION 6 98.44 Pressure Volume 2 Under Development 6 92.64 Nephrotoxicity 4 81.04 Acquired Immune Deficiency Syndrome Or Hiv Infection 8 77.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Importantly, NSAIDs significantly reduced the shift in adefovir cytotoxicity observed upon hOAT1 expression with ketoprofen and naproxen being 2- to 3-times more effective than probenecid.

Gene_expression (expression) of hOAT1 associated with cinod

1) Confidence 0.71 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991954 Disease Relevance 0.37 Pain Relevance 0.58

In an effort to look for novel inhibitors of this transport process, we used a cell line stably expressing hOAT1 to demonstrate that nonsteroidal anti-inflammatory drugs (NSAIDs) efficiently inhibit hOAT1-specific transport of adefovir at clinically relevant concentrations.

Gene_expression (expressing) of hOAT1 associated with inflammation and cinod

2) Confidence 0.71 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991954 Disease Relevance 0.48 Pain Relevance 0.34

Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured by inulin and para-aminohippurate (PAH) clearance, respectively.

Gene_expression (clearance) of para-aminohippurate in plasma

3) Confidence 0.59 Published 1991 Journal Anesthesiology Section Abstract Doc Link 2021202 Disease Relevance 0.39 Pain Relevance 0.41

Although hOAT1 and hOAT3 transported both aminopterin and methotrexate, uptake of methotrexate was greater in hOAT3-expressing oocytes than in hOAT1-expressing oocytes, and aminopterin was transported by hOAT1 more efficiently.

Gene_expression (expressing) of hOAT1 in oocytes associated with methotrexate

4) Confidence 0.53 Published 2010 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 20460822 Disease Relevance 0.05 Pain Relevance 0.35

Mouse proximal tubule cells stably expressing basolateral human organic anion transporters (hOAT1 and hOAT3) and apical hOAT (hOAT4) were established.

Gene_expression (expressing) of hOAT1 in proximal

5) Confidence 0.18 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130730 Disease Relevance 0.09 Pain Relevance 0.51

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