INT19157

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Context Info
Confidence 0.71
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.39
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (SLC22A6) plasma membrane (SLC22A6) protein complex (SLC22A6)
transmembrane transport (SLC22A6)
Anatomy Link Frequency
plasma 1
proximal 1
oocytes 1
SLC22A6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 19 99.16 Very High Very High Very High
methotrexate 20 99.02 Very High Very High Very High
anesthesia 3 98.72 Very High Very High Very High
isoflurane 5 93.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 98.44 Very High Very High Very High
Pressure Volume 2 Under Development 6 92.64 High High
Nephrotoxicity 4 81.04 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, NSAIDs significantly reduced the shift in adefovir cytotoxicity observed upon hOAT1 expression with ketoprofen and naproxen being 2- to 3-times more effective than probenecid.
Gene_expression (expression) of hOAT1 associated with cinod
1) Confidence 0.71 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991954 Disease Relevance 0.37 Pain Relevance 0.58
In an effort to look for novel inhibitors of this transport process, we used a cell line stably expressing hOAT1 to demonstrate that nonsteroidal anti-inflammatory drugs (NSAIDs) efficiently inhibit hOAT1-specific transport of adefovir at clinically relevant concentrations.
Gene_expression (expressing) of hOAT1 associated with inflammation and cinod
2) Confidence 0.71 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991954 Disease Relevance 0.48 Pain Relevance 0.34
Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured by inulin and para-aminohippurate (PAH) clearance, respectively.
Gene_expression (clearance) of para-aminohippurate in plasma
3) Confidence 0.59 Published 1991 Journal Anesthesiology Section Abstract Doc Link 2021202 Disease Relevance 0.39 Pain Relevance 0.41
Although hOAT1 and hOAT3 transported both aminopterin and methotrexate, uptake of methotrexate was greater in hOAT3-expressing oocytes than in hOAT1-expressing oocytes, and aminopterin was transported by hOAT1 more efficiently.
Gene_expression (expressing) of hOAT1 in oocytes associated with methotrexate
4) Confidence 0.53 Published 2010 Journal Drug Metab. Pharmacokinet. Section Abstract Doc Link 20460822 Disease Relevance 0.05 Pain Relevance 0.35
Mouse proximal tubule cells stably expressing basolateral human organic anion transporters (hOAT1 and hOAT3) and apical hOAT (hOAT4) were established.
Gene_expression (expressing) of hOAT1 in proximal
5) Confidence 0.18 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130730 Disease Relevance 0.09 Pain Relevance 0.51

General Comments

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