INT191589

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 7.08
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
monocytes 1
peritoneal macrophages 1
Msu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 425 99.52 Very High Very High Very High
agonist 3 99.20 Very High Very High Very High
anakinra 27 98.86 Very High Very High Very High
Arthritis 38 88.96 High High
Central nervous system 5 83.52 Quite High
Inflammatory response 36 71.92 Quite High
Hyperesthesia 8 66.72 Quite High
cytokine 91 59.80 Quite High
cINOD 19 42.48 Quite Low
corticosteroid 6 40.72 Quite Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 622 100.00 Very High Very High Very High
INFLAMMATION 468 99.52 Very High Very High Very High
Foreign Bodies 3 97.04 Very High Very High Very High
Thalassemia 4 96.64 Very High Very High Very High
Sickle Cell Anemia 39 96.00 Very High Very High Very High
Disease 14 93.08 High High
Peritonitis 21 88.72 High High
Syndrome 7 88.24 High High
Disorder Of Lipid Metabolism 3 83.56 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results show that MSU crystals initiate an inflammatory cascade, the starting point being the release of active IL-1?
Gene_expression (crystals) of MSU associated with inflammation and crystal associated disease
1) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.68 Pain Relevance 0.08
The ROS scavenger, N-acetylcysteine (NAC) inhibited both Hz- and MSU-induced IL-1?
Gene_expression (-) of MSU-induced
2) Confidence 0.44 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Surprisingly, the size of MSU crystals does not seem to be a major determinant of its inflammatory potential, as varying the mean crystal size between 2.0 and 11.8 ?
Gene_expression (crystals) of MSU associated with inflammation and crystal associated disease
3) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.99 Pain Relevance 0.25
Interestingly, co-stimulation of resident peritoneal macrophages with MSU crystals and an anti-TREM-1 agonist antibody synergistically increased the production of both IL-1?
Gene_expression (crystals) of MSU in peritoneal macrophages associated with agonist and crystal associated disease
4) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.08 Pain Relevance 0.36
g anakinra (Kineret; Amgen, Thousand Oaks, CA, USA) at the time of MSU injection.
Gene_expression (injection) of MSU associated with anakinra and crystal associated disease
5) Confidence 0.35 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.88 Pain Relevance 0.21
Validating induction of Hdc, TREM-1, PUMA-g, Irg1 and PROK-2 mRNAs by MSU crystals in the air pouch membrane
Gene_expression (crystals) of MSU associated with crystal associated disease
6) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.22 Pain Relevance 0.03
The induction of TREM-1 in macrophages by MSU crystals has been reported [26].
Gene_expression (crystals) of MSU in macrophages associated with crystal associated disease
7) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.65 Pain Relevance 0
Of these, the 12 most highly over-expressed (linear ratio MSU/control >17) targets are listed in Table 1.
Gene_expression (expressed) of MSU associated with crystal associated disease
8) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.48 Pain Relevance 0.06
IL-6 is known to be raised in gout [17], but it had not been studied in the MSU-stimulated murine air pouch. qPCR validation of its expression in the 50-hour time course experiment summarized in Figure 1 was therefore chosen to establish proof of principle of the microrray approach.
Gene_expression (expression) of MSU associated with crystal associated disease
9) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.42 Pain Relevance 0.11
When MSU crystals were added to monocytes in culture, both IL-1?
Gene_expression (crystals) of MSU in monocytes associated with crystal associated disease
10) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 1.02 Pain Relevance 0.24
There were 32 patients with abnormal first MSUs: 29 were positive MSU samples growing identifiable pathogens (Figure 1), 2 were grossly contaminated and one grew bacteria of doubtful significance (growth of a urinary tract pathogen between 104 and 105 per mL).
Gene_expression (samples) of MSU
11) Confidence 0.04 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1434754 Disease Relevance 0.67 Pain Relevance 0

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