INT191601

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.13
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Fdft1) endoplasmic reticulum (Fdft1) biosynthetic process (Fdft1)
transferase activity, transferring alkyl or aryl (other than methyl) groups (Fdft1)
Fdft1 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 1 87.68 High High
Hippocampus 8 77.52 Quite High
long-term potentiation 5 76.76 Quite High
antagonist 1 74.20 Quite High
gABA 7 68.76 Quite High
dopamine receptor 8 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 1 96.04 Very High Very High Very High
Cognitive Disorder 18 93.28 High High
Hepatomegaly 2 91.48 High High
Splenomegaly 3 90.68 High High
Myelodysplastic Syndromes 38 87.08 High High
Myelofibrosis 30 86.48 High High
Thrombosis 1 85.72 High High
Thrombocytopenia 1 84.20 Quite High
Anaemia 1 83.24 Quite High
Myeloproliferative Disorder 45 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ras activity within cells can also be modulated through the introduction of farnesyl-transferase inhibitors.
Negative_regulation (inhibitors) of farnesyl-transferase
1) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.56 Pain Relevance 0.24
A number of novel therapeutic strategies have been explored in these patients including farnesyl-transferase inhibition [19], proteosome inhibition [20] and immunomodulation with lenalidomide [21] but with limited efficacy.
Negative_regulation (inhibition) of farnesyl-transferase
2) Confidence 0.01 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 1.57 Pain Relevance 0.09

General Comments

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