INT191618

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Context Info
Confidence 0.35
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 9
Disease Relevance 3.77
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (App, Nf1) cytoplasm (App, Nf1) Golgi apparatus (App)
intracellular (Nf1) DNA binding (App) protein complex (Nf1)
App (Mus musculus)
Nf1 (Mus musculus)
Pain Link Frequency Relevance Heat
dopamine receptor 72 99.24 Very High Very High Very High
long-term potentiation 45 93.20 High High
Hippocampus 72 85.84 High High
gABA 63 85.04 High High
nMDA receptor 9 83.00 Quite High
Dopamine 18 77.52 Quite High
imagery 9 73.12 Quite High
positron emission tomography 9 70.88 Quite High
Neurobehavioral 9 45.24 Quite Low
cerebral cortex 9 43.04 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 27 100.00 Very High Very High Very High
Watson Syndrome 252 89.76 High High
Cognitive Disorder 162 75.00 Quite High
Targeted Disruption 54 75.00 Quite High
Learning Disorders 18 49.44 Quite Low
Attention Deficit Hyperactivity Disorder 18 47.92 Quite Low
Ganglion Cysts 9 38.64 Quite Low
Shock 18 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Macrocephaly 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The networking program also identified neurofibromin as a physical binding partner with both the kinesin heavy chain and amyloid beta precursor protein (APP) (Fig. 2).
APP Binding (binding) of neurofibromin associated with alzheimer's dementia
1) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.10 Pain Relevance 0.16
These potential interactions between neurofibromin and APP or DRD3 might lead to new ideas about how neurofibromin is involved in cellular signaling and synaptic plasticity.
APP Binding (interactions) of neurofibromin
2) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.38 Pain Relevance 0.31
Through this analysis, it is proposed that neurofibromin forms a binding complex with amyloid precursor protein (APP) and through filamin proteins interacts with a dopamine receptor (Drd3).
APP Binding (complex) of neurofibromin associated with dopamine receptor and alzheimer's dementia
3) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1434756 Disease Relevance 0.53 Pain Relevance 0.17
Through this analysis, it is proposed that neurofibromin forms a binding complex with amyloid precursor protein (APP) and through filamin proteins interacts with a dopamine receptor (Drd3).
amyloid precursor protein Binding (forms) of neurofibromin associated with dopamine receptor and alzheimer's dementia
4) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1434756 Disease Relevance 0.53 Pain Relevance 0.17
Through this analysis, it is proposed that neurofibromin forms a binding complex with amyloid precursor protein (APP) and through filamin proteins interacts with a dopamine receptor (Drd3).
amyloid precursor protein Binding (complex) of neurofibromin associated with dopamine receptor and alzheimer's dementia
5) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1434756 Disease Relevance 0.53 Pain Relevance 0.17
The networking program also identified neurofibromin as a physical binding partner with both the kinesin heavy chain and amyloid beta precursor protein (APP) (Fig. 2).
APP Binding (partner) of neurofibromin associated with alzheimer's dementia
6) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.10 Pain Relevance 0.16
Through this analysis, it is proposed that neurofibromin forms a binding complex with amyloid precursor protein (APP) and through filamin proteins interacts with a dopamine receptor (Drd3).
APP Binding (forms) of neurofibromin associated with dopamine receptor and alzheimer's dementia
7) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1434756 Disease Relevance 0.53 Pain Relevance 0.17
Through this analysis, it is proposed that neurofibromin forms a binding complex with amyloid precursor protein (APP) and through filamin proteins interacts with a dopamine receptor (Drd3).
APP Binding (binding) of neurofibromin associated with dopamine receptor and alzheimer's dementia
8) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1434756 Disease Relevance 0.53 Pain Relevance 0.17
Through this analysis, it is proposed that neurofibromin forms a binding complex with amyloid precursor protein (APP) and through filamin proteins interacts with a dopamine receptor (Drd3).
amyloid precursor protein Binding (binding) of neurofibromin associated with dopamine receptor and alzheimer's dementia
9) Confidence 0.26 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1434756 Disease Relevance 0.53 Pain Relevance 0.17

General Comments

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