INT191653

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GGPS1) small molecule metabolic process (GGPS1) cytoplasm (GGPS1)
GGPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 33 88.64 High High
Prostate Cancer 15 80.12 Quite High
Apoptosis 9 5.00 Very Low Very Low Very Low
Hypercalcemia 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low
Ovarian Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ZOL impairs Rap1A geranyl-geranylation by preventing GGPP production and not GGPP incorporation into the protein
Negative_regulation (preventing) of Gene_expression (production) of GGPP
1) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0 Pain Relevance 0
Indeed, some studies support the inhibition of FPP synthase, impairing FPP, and consequently GGPP, production [7-9,15,17], whereas other teams suggest the existence of an additional enzymatic target of N-BPs, downstream of FPP synthase [11,12,34].
Negative_regulation (impairing) of Gene_expression (production) of GGPP
2) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.08 Pain Relevance 0
So, inhibition of geranyl-geranylation by ZOL appears to result from a blockade in GGPP synthesis from FPP rather than from the inhibition of the enzymatic transfer of GGPP onto its protein substrate.


Negative_regulation (blockade) of Gene_expression (synthesis) of GGPP
3) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.22 Pain Relevance 0

General Comments

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