INT191653

Context Info Confidence 0.03 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.30 Pain Relevance 0

cytosol (GGPS1) small molecule metabolic process (GGPS1) cytoplasm (GGPS1)

GGPS1 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 3 5.00 Potency 3 5.00

Disease Link Frequency Relevance Heat Stress 33 88.64 Prostate Cancer 15 80.12 Apoptosis 9 5.00 Hypercalcemia 6 5.00 Cancer 6 5.00 Pain 3 5.00 Breast Cancer 3 5.00 Ovarian Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ZOL impairs Rap1A geranyl-geranylation by preventing GGPP production and not GGPP incorporation into the protein

Negative_regulation (preventing) of Gene_expression (production) of GGPP

1) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0 Pain Relevance 0

Indeed, some studies support the inhibition of FPP synthase, impairing FPP, and consequently GGPP, production [7-9,15,17], whereas other teams suggest the existence of an additional enzymatic target of N-BPs, downstream of FPP synthase [11,12,34].

Negative_regulation (impairing) of Gene_expression (production) of GGPP

2) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.08 Pain Relevance 0

So, inhibition of geranyl-geranylation by ZOL appears to result from a blockade in GGPP synthesis from FPP rather than from the inhibition of the enzymatic transfer of GGPP onto its protein substrate.

Negative_regulation (blockade) of Gene_expression (synthesis) of GGPP

3) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.22 Pain Relevance 0

General Comments

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