INT191656

Context Info Confidence 0.03 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.65 Pain Relevance 0

cytosol (FDPS) mitochondrion (FDPS) small molecule metabolic process (FDPS) nucleolus (FDPS) nucleus (FDPS) cytoplasm (FDPS)

FDPS (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 2 5.00 Potency 2 5.00

Disease Link Frequency Relevance Heat Cancer 4 97.06 Apoptosis 6 95.32 Stress 22 89.36 Prostate Cancer 10 86.92 Breast Cancer 2 47.96 Ovarian Cancer 2 45.92 Hypercalcemia 4 5.00 Pain 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The anti-tumor effect of alendronate, ZOL and PAM was correlated to their inhibition of the MWA pathway in prostate cells [15,17], favoring the hypothesis of an inhibition of FPP synthesis, protein geranyl-geranylation was not assessed although GGOH appeared more effective than FOH to rescue ZOL-induced apoptosis.

Negative_regulation (inhibition) of Gene_expression (synthesis) of FPP associated with cancer and apoptosis

1) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.43 Pain Relevance 0

So, inhibition of geranyl-geranylation by ZOL appears to result from a blockade in GGPP synthesis from FPP rather than from the inhibition of the enzymatic transfer of GGPP onto its protein substrate.

Negative_regulation (blockade) of Gene_expression (synthesis) of FPP

2) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.22 Pain Relevance 0

General Comments

This test has worked.