INT191656
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The anti-tumor effect of alendronate, ZOL and PAM was correlated to their inhibition of the MWA pathway in prostate cells [15,17], favoring the hypothesis of an inhibition of FPP synthesis, protein geranyl-geranylation was not assessed although GGOH appeared more effective than FOH to rescue ZOL-induced apoptosis. | |||||||||||||||
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So, inhibition of geranyl-geranylation by ZOL appears to result from a blockade in GGPP synthesis from FPP rather than from the inhibition of the enzymatic transfer of GGPP onto its protein substrate.
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General Comments
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