INT191656

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FDPS) mitochondrion (FDPS) small molecule metabolic process (FDPS)
nucleolus (FDPS) nucleus (FDPS) cytoplasm (FDPS)
FDPS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 97.06 Very High Very High Very High
Apoptosis 6 95.32 Very High Very High Very High
Stress 22 89.36 High High
Prostate Cancer 10 86.92 High High
Breast Cancer 2 47.96 Quite Low
Ovarian Cancer 2 45.92 Quite Low
Hypercalcemia 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-tumor effect of alendronate, ZOL and PAM was correlated to their inhibition of the MWA pathway in prostate cells [15,17], favoring the hypothesis of an inhibition of FPP synthesis, protein geranyl-geranylation was not assessed although GGOH appeared more effective than FOH to rescue ZOL-induced apoptosis.
Negative_regulation (inhibition) of Gene_expression (synthesis) of FPP associated with cancer and apoptosis
1) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.43 Pain Relevance 0
So, inhibition of geranyl-geranylation by ZOL appears to result from a blockade in GGPP synthesis from FPP rather than from the inhibition of the enzymatic transfer of GGPP onto its protein substrate.


Negative_regulation (blockade) of Gene_expression (synthesis) of FPP
2) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.22 Pain Relevance 0

General Comments

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