INT191658

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.06
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GGPS1) small molecule metabolic process (GGPS1) cytoplasm (GGPS1)
GGPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 3 71.76 Quite High
metalloproteinase 2 64.80 Quite High
Inflammation 75 56.84 Quite High
cytokine 29 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
Angina 11 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 88 56.84 Quite High
Acute Coronary Syndrome 38 50.00 Quite Low
Aging 21 50.00 Quite Low
Cardiovascular Disease 26 28.52 Quite Low
Stress 15 17.84 Low Low
Death 13 8.24 Low Low
Myeloid Leukemia 2 8.00 Low Low
Atherosclerosis 44 5.00 Very Low Very Low Very Low
Osteoporosis 35 5.00 Very Low Very Low Very Low
Diabetes Mellitus 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and atorvastatin in the presence or absence of mevalonate, FPP, and GGPP to determine whether atorvastatin inhibition of ENA-78 production was dependent on HMG-CoA reductase inhibition and subsequent downstream pathways.
Negative_regulation (absence) of GGPP
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518836 Disease Relevance 0 Pain Relevance 0
Alendronate did not inhibit isopentenyl diphosphate isomerase or GGPP synthase.
Negative_regulation (inhibit) of GGPP synthase
2) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.06 Pain Relevance 0.13
To challenge these two hypotheses, we tested the ability of ZOL to prevent GGPP incorporation into substrate proteins in vitro and in vivo.
Negative_regulation (prevent) of GGPP
3) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0 Pain Relevance 0

General Comments

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